5%CE%B1-Dihydrodeoxycorticosterone/Dihydrodeoxycorticosterone, 5%CE%B1-Dihydroethisterone/5α-Dihydroethisterone

5% CE% B1-Dihydrodeoxycorticosterone / Dihydrodeoxycorticosterone: 5α-Dihydrodeoxycorticosterone , izwi kandi nka 21-hydroxy-5α-gutwita-20-imwe , ni progestogene ya endogenous na neurosteroid. Ihindurwamo imisemburo ya adrenal deoxycorticosterone (DOC) na enzyme 5α-reductase yo mu bwoko bwa I. DHDOC ni agoniste wa reseptor ya progesterone, ndetse na moderi nziza ya allosteric modulator ya reseptor ya GABA A , kandi izwiho kugira ingaruka za anticonvulsant.
5% CE% B1-Dihydroethisterone / 5α-Dihydroethisterone: 5α-Dihydroethisterone ni metabolite Gikora ya kera abaganga gukoreshwa ariko ubu-yahagaze progestin ethisterone na igerageza no rimwe-marketed imisemburo antineoplastic agent ethynylandrostanediol (HE-3235). Imiterere yabyo ituruka kumiti yababyeyi iterwa na 5α-reductase mumyanya igaragaza enzyme mubwinshi nkumwijima, uruhu, imisatsi, na glande ya prostate. 5α-DHET ifitanye isano ikomeye no kwakira imisemburo ya steroid kandi ishobora kugira uruhare runini mubikorwa byibiyobyabwenge byababyeyi.
5% CE% B1-Dihydroethylestrenolone / 5α-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5α-DHNED ), izwi kandi nka 17α-ethyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-ethyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid na metabolite ya norethandrolone yakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNED yerekana kugabanuka kwakirwa na reseptor ya androgene ugereranije na norethandrolone. Kuba hafi ya androgene yakira ni hafi 64% bya norethandrolone.
5% CE% B1-Dihydrofluoxymesterone / Dihydrofluoxymesterone: Dihydrofluoxymesterone ni androgene na anabolike steroid (AAS) itigeze igurishwa. Yasuzumwe mu kuvura kanseri y'ibere ku bagore mu bushakashatsi nibura bumwe mu mavuriro mu myaka ya za 70 kandi bugaragaza imikorere isa n'iy'abandi AAS. Umuti ni 5α wagabanutse analogue na metabolite ya fluoxymesterone.
5% CE% B1-Dihydrolevonorgestrel / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-Dihydromethylnandrolone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-Dihydromethylnortestosterone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-Dihydronandrolone / 5α-Dihydronandrolone: 5α-Dihydronandrolone nibisanzwe bibaho anabolike - androgeneque steroid (AAS) hamwe na 5α yagabanutse ikomoka kuri nandrolone (19-nortestosterone). Ni metabolite ikomeye ya nandrolone kandi ikorwa muri yo n'ibikorwa bya enzyme 5α-reductase bisa no gushiraho dihydrotestosterone (DHT) ivuye muri testosterone.
5% CE% B1-Dihydronorethandrolone / 5α-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5α-DHNED ), izwi kandi nka 17α-ethyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-ethyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid na metabolite ya norethandrolone yakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNED yerekana kugabanuka kwakirwa na reseptor ya androgene ugereranije na norethandrolone. Kuba hafi ya androgene yakira ni hafi 64% bya norethandrolone.
5% CE% B1-Dihydronorethindrone / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-Dihydronorethisterone / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-Dihydronorgestrel / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-Dihydronormethandrone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-Dihydronormethyltestosterone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-Dihydroprogesterone / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-Dihydrotestosterone / Dihydrotestosterone: Dihydrotestosterone ni endogenous androgen igitsina steroid na hormone. Enzyme 5α-reductase itera ishingwa rya DHT kuva testosterone mubice bimwe na bimwe birimo glande ya prostate, vitamine seminal, epididymide, uruhu, imisatsi, umwijima, n'ubwonko. Iyi misemburo ihuza kugabanya C4-5 inshuro ebyiri za testosterone. Ugereranije na testosterone, DHT irakomeye cyane nka agonist ya reseptor ya androgene (AR).
5% CE% B1-Dihydrotestosterone 17% CE% B2-undecanoate / Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), izwi kandi nka androstanolone undecanoate cyangwa stanolone undecanoate , ni sintetike ya androgene na anabolike steroid (AAS) itigeze igurishwa. Ni estrogene ester; byumwihariko, ni C17β idasobanutse (undecylate) ester ya dihydrotestosterone (DHT). DHTU ni prodrug ya DHT. Kimwe na testosterone idasobanutse (TU), DHTU irakora kumanwa. Bibaho nkingirakamaro ya metabolite yingirakamaro ya TU. 5α-reductase inhibitor finasteride ifatanije na TU yo mu kanwa nta ngaruka igira ku ihinduka ryambere rya TU muri DHTU cyangwa DHT, birashoboka kubera inzira yihariye ya lymphatique yo kwinjirira. DHTU yo mu kanwa irashobora kwinjizwa na sisitemu ya lymphatike isa na TU, kandi ibi birashobora gusobanura bioavailable yo mu kanwa.
5% CE% B1-Dihydrotestosterone 17% CE% B2-undecylate / Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), izwi kandi nka androstanolone undecanoate cyangwa stanolone undecanoate , ni sintetike ya androgene na anabolike steroid (AAS) itigeze igurishwa. Ni estrogene ester; byumwihariko, ni C17β idasobanutse (undecylate) ester ya dihydrotestosterone (DHT). DHTU ni prodrug ya DHT. Kimwe na testosterone idasobanutse (TU), DHTU irakora kumanwa. Bibaho nkingirakamaro ya metabolite yingirakamaro ya TU. 5α-reductase inhibitor finasteride ifatanije na TU yo mu kanwa nta ngaruka igira ku ihinduka ryambere rya TU muri DHTU cyangwa DHT, birashoboka kubera inzira yihariye ya lymphatique yo kwinjirira. DHTU yo mu kanwa irashobora kwinjizwa na sisitemu ya lymphatike isa na TU, kandi ibi birashobora gusobanura bioavailable yo mu kanwa.
5% CE% B1-Estran-17% CE% B2-ol-3-umwe / 5α-Dihydronandrolone: 5α-Dihydronandrolone nibisanzwe bibaho anabolike - androgeneque steroid (AAS) hamwe na 5α yagabanutse ikomoka kuri nandrolone (19-nortestosterone). Ni metabolite ikomeye ya nandrolone kandi ikorwa muri yo n'ibikorwa bya enzyme 5α-reductase bisa no gushiraho dihydrotestosterone (DHT) ivuye muri testosterone.
5% CE% B1-LNG / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-Pregnan-17% CE% B1-ol-3,20-dione / 5α-Pregnan-17α-ol-3,20-dione: 5α-Pregnan-17α-ol-3,20-dione , izwi kandi nka 17α-hydroxy-dihydroprogesterone ( 17 - OH-DHP ) ni steroid ya endogenous.
5% CE% B1-Pregnan-3,20-dione / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-Inda-3% CE% B1,20% CE% B1-diol / Allopregnanediol: Allopregnanediol , cyangwa 5α-gutwita-3α, 20α-diol , ni metabolite ya endogenous ya progesterone na allopregnanolone hamwe na isomer wa womediediol (5β-gutwita-3α, 20α-diol). Byagaragaye ko bikora nka agonist igice cyurubuga rwa allosteric ya reseptor ya GABA bityo bikaba bishobora kugira uruhare mubinyabuzima nka neurosteroid. Byagaragaye kandi ko ikora nka agonist ya reseptor ya muntu itwite X, nubwo ifite EC 50 irenze gahunda yubunini buri munsi ugereranije nizindi nda zitwite endogène nka gutwita, gutwita, allopregnanedione, na allopregnanolone.
5% CE% B1-Gutwita / Allopregnane: 5α-Pregnane , izwi kandi nka Allopregnane cyangwa nka 10β, 13β-dimethyl-17β-ethyl-5α-gonane , ni steroid hamwe n'ababyeyi bavanga ibintu bitandukanye bikomoka kuri steroid. Nimwe muri epimers yo gutwita, indi ni 5β-inda. Ibikomoka kuri Allopregnane harimo steroide isanzwe ibaho Allopregnanolone, Allopregnanediol, Isopregnanolone, na 5α-Dihydroprogesterone.
5% CE% B1-Gutwita-3,20-dione / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-Inda-3% CE% B1,17% CE% B1-diol-20-umwe / 5α-Pregnane-3α, 17α-diol-20-imwe: 5α-Pregnane-3α, 17α-diol-20-imwe , izwi kandi nka 17α-hydroxyallopregnanolone ( 17-OH-allo ) ni steroid ya endogenous.
5% CE% B1-Gutwita-3% CE% B1,20% CE% B1-diol / Allopregnanediol: Allopregnanediol , cyangwa 5α-gutwita-3α, 20α-diol , ni metabolite ya endogenous ya progesterone na allopregnanolone hamwe na isomer wa womediediol (5β-gutwita-3α, 20α-diol). Byagaragaye ko bikora nka agonist igice cyurubuga rwa allosteric ya reseptor ya GABA bityo bikaba bishobora kugira uruhare mubinyabuzima nka neurosteroid. Byagaragaye kandi ko ikora nka agonist ya reseptor ya muntu itwite X, nubwo ifite EC 50 irenze gahunda yubunini buri munsi ugereranije nizindi nda zitwite endogène nka gutwita, gutwita, allopregnanedione, na allopregnanolone.
5% CE% B1-Gutwita / Allopregnanediol: Allopregnanediol , cyangwa 5α-gutwita-3α, 20α-diol , ni metabolite ya endogenous ya progesterone na allopregnanolone hamwe na isomer wa womediediol (5β-gutwita-3α, 20α-diol). Byagaragaye ko bikora nka agonist igice cyurubuga rwa allosteric ya reseptor ya GABA bityo bikaba bishobora kugira uruhare mubinyabuzima nka neurosteroid. Byagaragaye kandi ko ikora nka agonist ya reseptor ya muntu itwite X, nubwo ifite EC 50 irenze gahunda yubunini buri munsi ugereranije nizindi nda zitwite endogène nka gutwita, gutwita, allopregnanedione, na allopregnanolone.
5% CE% B1-Gutwita / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-Kugabanya / 5α-Kugabanya: 5α-reductase , izwi kandi nka 3-oxo-5α-steroid 4-dehydrogenase , ni enzymes zigira uruhare muri metabolism ya steroid. Bitabira inzira 3 zo guhinduranya: aside aside biosynthesis, androgene na metabolism ya estrogene. Hano hari isozymes eshatu za 5α-reductase, SRD5A1, SRD5A2, na SRD5A3, zitandukanye mubice bitandukanye hamwe nimyaka.
5% CE% B1-Kugabanya 2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-Kugabanya 2_ubuke / 5α-Kugabanya ibura: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1-Kugabanya I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1-Kugabanya II / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-Kugabanya kubura / 5α-Kugabanya ibura: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1-Kugabanya inhibitor / 5α-Kugabanya inhibitor: 5α-Kugabanya inhibitori ( 5-ARIs ), izwi kandi nka dihydrotestosterone ( DHT ) ikumira , ni urwego rwimiti ifite ingaruka za antandrogeneque zikoreshwa cyane cyane mukuvura prostate nini no guta umusatsi. Rimwe na rimwe zikoreshwa mu kuvura imikurire ikabije ku bagore kandi nkigice cyo kuvura imisemburo ku bagore bahindura ibitsina.
5% CE% B1-Kugabanya inzitizi / 5α-Kugabanya inhibitor: 5α-Kugabanya inhibitori ( 5-ARIs ), izwi kandi nka dihydrotestosterone ( DHT ) ikumira , ni urwego rwimiti ifite ingaruka za antandrogeneque zikoreshwa cyane cyane mukuvura prostate nini no guta umusatsi. Rimwe na rimwe zikoreshwa mu kuvura imikurire ikabije ku bagore kandi nkigice cyo kuvura imisemburo ku bagore bahindura ibitsina.
5% CE% B1-Kugabanya ubwoko_1 / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1-Kugabanya ubwoko_2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-Kugabanya ubwoko_2_ibura / 5α-Kugabanya: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1-Kugabanya ubwoko_I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1-Kugabanya ubwoko_II / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-Kugabanya ubwoko_II_ibura / 5α-Kugabanya: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1-androst-1-ene-3,17-dione / 1-Androstenedione: 1-Androstenedione , cyangwa 5α-androst-1-ene-3,17-dione , izwi kandi nka 4,5α-dihydro-δ 1 -4-androstenedione , ni sintetike ya androgene na anabolike steroid. Ni 5α yagabanijwe isomer ya endogenous steroid 4-androstenedione kandi ikora nka prohormone ya androgene ya 1-testosterone (4,5α-dihydro-δ 1 -testosterone), ikomoka kuri dihydrotestosterone (DHT).
5% CE% B1-androst-1-ene-3% CE% B2,17% CE% B2-diol / 1-Androstenediol: 1-Androstenediol , cyangwa 5α-androst-1-ene-3β, 17β-diol , izwi kandi nka 4,5α-dihydro-δ 1 -4-androstenediol , ni porhormone ya 1-testosterone (Δ 1 - DHT ).
5% CE% B1-androst-16-en-3% CE% B1-ol / Androstenol: Androstenol , izwi kandi nka 5α-androst-16-en-3α-ol , ni feromone ya steroidal na neurosteroid mu bantu no mu yandi matungo y'inyamabere, cyane cyane ingurube. Ifite umunuko uranga impumuro nziza.
5% CE% B1-androst-16-en-3% CE% B2-ol / 3β-Androstenol: 3β-Androstenol , izwi kandi nka 5α-androst-16-en-3β-ol , ni feromone y'inyamabere isanzwe ibaho izwiho kuba mu bantu ningurube. Byatekerejweho kugira uruhare mumpumuro nziza. Ikorwa muri androstenone ikoresheje enzyme 3β-hydroxysteroid dehydrogenase. Bitandukanye na C3α epimer yayo 3α-androstenol, 3β-androstenol yerekana ko nta mbaraga za GABA A reseptor cyangwa ibikorwa bya anticonvulsant.
5% CE% B1-androst-16-en-4-umwe / Androstenone: Androstenone ( 5α-androst-16-en-3-imwe ) ni feromone ya steroidal. Biboneka mu macandwe y'ingurube, seleri cytoplazme, na truffle fungus. Androstenone niyo feromone yambere yinyamabere yamenyekanye. Iboneka cyane mumacandwe yingurube zabagabo, kandi, iyo ihumetse ningurube yumugore iri mubushuhe, bivamo igitsina gore gufata icyemezo cyo gushyingiranwa. Androstenone ni ingirakamaro muri 'Boarmate', igicuruzwa cyakozwe na DuPont cyagurishijwe ku bahinzi b'ingurube kugira ngo bapime imbuto ku gihe cyo gutera intanga.
5% CE% B1-androst-2-en-17-umwe / 5α-Androst-2-ene-17-umwe: 5α-Androst-2-en-17-imwe ni endogenous, isanzwe ibaho, mu kanwa ikora anabolike-androgeneque steroid (AAS) kandi ikomoka kuri dihydrotestosterone (DHT). Ni metabolite ya dehydroepiandrosterone (DHEA) mu mubiri kandi ni na feromone iboneka mu nzovu n'ingurube. 5α-Androst-2-en-17-imwe yagurishijwe kuri interineti nk "inyongera yimirire". Irasa na desoxymethyltestosterone (17α-methyl-5α-androst-2-en-17β-ol) mu miterere yimiti kandi irashobora gukora nka porogoro ya androgene.
5% CE% B1-androst-2-ene-17-umwe / 5α-Androst-2-ene-17-umwe: 5α-Androst-2-en-17-imwe ni endogenous, isanzwe ibaho, mu kanwa ikora anabolike-androgeneque steroid (AAS) kandi ikomoka kuri dihydrotestosterone (DHT). Ni metabolite ya dehydroepiandrosterone (DHEA) mu mubiri kandi ni na feromone iboneka mu nzovu n'ingurube. 5α-Androst-2-en-17-imwe yagurishijwe kuri interineti nk "inyongera yimirire". Irasa na desoxymethyltestosterone (17α-methyl-5α-androst-2-en-17β-ol) mu miterere yimiti kandi irashobora gukora nka porogoro ya androgene.
5% CE% B1-androstan-17% CE% B2-ol-3,11-dione / 11-Ketodihydrotestosterone: 11-Ketodihydrotestosterone ( 11-KDHT ), izwi kandi nka 5α-androstan-17β-ol-3,11-dione , ni endogenous, isanzwe ibaho steroid na androgene prohormone ikorwa cyane cyane, niba atari wenyine, muri glande ya adrenal. Ifitanye isano ya hafi na 11β-hydroxyandrostenedione (11β-KA4), adrenosterone, na 11-ketotestosterone (11-KT), nayo ikorerwa muri glande ya adrenal.
5% CE% B1-androstan-17% CE% B2-ol-3-umwe / Dihydrotestosterone: Dihydrotestosterone ni endogenous androgen igitsina steroid na hormone. Enzyme 5α-reductase itera ishingwa rya DHT kuva testosterone mubice bimwe na bimwe birimo glande ya prostate, vitamine seminal, epididymide, uruhu, imisatsi, umwijima, n'ubwonko. Iyi misemburo ihuza kugabanya C4-5 inshuro ebyiri za testosterone. Ugereranije na testosterone, DHT irakomeye cyane nka agonist ya reseptor ya androgene (AR).
5% CE% B1-androstane / Androstane: Androstane ni C19 steroid hamwe na gonane yibanze. Androstane irashobora kubaho nka kimwe muri bibiri bya isomers, bizwi nka 5α-androstane na 5β-androstane .
5% CE% B1-androstane-3% CE% B1,17% CE% B2-diol / 3α-Androstanediol: 3α-Androstanediol izwi kandi nka 5α-androstane-3α, 17β-diol ndetse rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3α-diol , ni imisemburo ya endogenous steroid na neurosteroid na metabolite ya andorogene nka dihydrotestosterone (DHT).
5% CE% B1-androstane-3% CE% B2,17% CE% B2-diol / 3β-Androstanediol: 3β-Androstanediol , izwi kandi nka 5α-androstane-3β, 17β-diol , kandi rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3β-diol , ni imisemburo ya endogenous steroid na metabolite ya androgene nka dehydroepiandrosterone (DHEA) na dihydrotestosterone (DHT).
5% CE% B1-androstanediol / Androstanediol: Androstanediol irashobora kwerekeza kuri: 3α-Androstanediol (5α-androstane-3α, 17β-diol) - endosterous neurosteroid, androgene idakomeye na estrogene, kandi hagati ya androsterone 3β-Androstanediol (5α-androstane-3β, 17β-diol) - estrogene ya endogene kandi hagati ya epiandrosterone 3α-Etiocholanediol - hagati ya endogenous hagati ya etiocholanolone 3β-Etiocholanediol - interogenous intermedia hagati ya epietiocholanolone
5% CE% B1-androstanedione / Androstanedione: Androstanedione, uzwi 5α-androstanedione cyangwa nk'uko 5α-androstane-3,17-dione, ni androstane bisanzwe biriko (5α-androstane) steroid kandi endogenous metabolite ya androgens nka testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), androstenedione. Ni C5 epimer ya etiocholanedione (5β-androstanedione). Androstanedione ikorwa kuva androstenedione na 5α-reductase na DHT na 17β-hydroxysteroid dehydrogenase. Ifite ibikorwa bimwe na bimwe bya androgene.
5% CE% B1-androstenone / Androstenone: Androstenone ( 5α-androst-16-en-3-imwe ) ni feromone ya steroidal. Biboneka mu macandwe y'ingurube, seleri cytoplazme, na truffle fungus. Androstenone niyo feromone yambere yinyamabere yamenyekanye. Iboneka cyane mumacandwe yingurube zabagabo, kandi, iyo ihumetse ningurube yumugore iri mubushuhe, bivamo igitsina gore gufata icyemezo cyo gushyingiranwa. Androstenone ni ingirakamaro muri 'Boarmate', igicuruzwa cyakozwe na DuPont cyagurishijwe ku bahinzi b'ingurube kugira ngo bapime imbuto ku gihe cyo gutera intanga.
5% CE% B1-dihydro-17% CE% B1-ethynyl-19-nortestosterone / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-dihydro-17% CE% B1-Ethynyltestosterone / 5α-Dihydroethisterone: 5α-Dihydroethisterone ni metabolite Gikora ya kera abaganga gukoreshwa ariko ubu-yahagaze progestin ethisterone na igerageza no rimwe-marketed imisemburo antineoplastic agent ethynylandrostanediol (HE-3235). Imiterere yabyo ituruka kumiti yababyeyi iterwa na 5α-reductase mumyanya igaragaza enzyme mubwinshi nkumwijima, uruhu, imisatsi, na glande ya prostate. 5α-DHET ifitanye isano ikomeye no kwakira imisemburo ya steroid kandi ishobora kugira uruhare runini mubikorwa byibiyobyabwenge byababyeyi.
5% CE% B1-dihydro-19-norethisterone / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-dihydro-NET / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-dihydro-Ethylestrenolone / 5α-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5α-DHNED ), izwi kandi nka 17α-ethyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-ethyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid na metabolite ya norethandrolone yakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNED yerekana kugabanuka kwakirwa na reseptor ya androgene ugereranije na norethandrolone. Kuba hafi ya androgene yakira ni hafi 64% bya norethandrolone.
5% CE% B1-dihydro-fluoxymesterone / Dihydrofluoxymesterone: Dihydrofluoxymesterone ni androgene na anabolike steroid (AAS) itigeze igurishwa. Yasuzumwe mu kuvura kanseri y'ibere ku bagore mu bushakashatsi nibura bumwe mu mavuriro mu myaka ya za 70 kandi bugaragaza imikorere isa n'iy'abandi AAS. Umuti ni 5α wagabanutse analogue na metabolite ya fluoxymesterone.
5% CE% B1-dihydro-levonorgestrel / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-dihydro-norethandrolone / 5α-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5α-DHNED ), izwi kandi nka 17α-ethyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-ethyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid na metabolite ya norethandrolone yakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNED yerekana kugabanuka kwakirwa na reseptor ya androgene ugereranije na norethandrolone. Kuba hafi ya androgene yakira ni hafi 64% bya norethandrolone.
5% CE% B1-dihydro-norgestrel / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-dihydroaldosterone / 5α-Dihydroaldosterone: 5α-Dihydroaldosterone ni metabolite ya aldosterone ikorwa na 5α-reductase. Nibintu bikomeye birwanya antinatriuretic bisa ariko ariko bitandukanye na aldosterone. Ikorerwa mu mpyiko.
5% CE% B1-dihydrocorticosterone / 5α-Dihydrocorticosterone: 5α-Dihydrocorticosterone , izwi kandi nka 11β, 21-dihydroxy-5α-gutwita-3,20-dione , ni ibisanzwe bisanzwe, imisemburo ya glucocorticoid steroid na neurosteroid. Ni biosynthesize kuva corticosterone na enzyme 5α-reductase. DHC ifite ingaruka zo kwiheba no kwangiza imbaraga z'igihe kirekire mu nyamaswa.
5% CE% B1-dihydrocortisol / 5α-Dihydrocortisol: 5α-Dihydrocortisol ( 5α-DHF ), izwi kandi nka hydrallostane cyangwa nka allodihydrocortisol , ni metabolite ya cortisol ikorwa na 5α-reductase. Iraboneka murwenya rwamazi rwijisho, ikorerwa mumurongo wijisho, kandi ikagira uruhare mukugenzura imiterere yimikino yo mumazi. 5α-DHF irashobora guhindurwa muburyo bwa 3α, 5α-tetrahydrocortisol na 3α-hydroxysteroid dehydrogenase.
5% CE% B1-dihydrodeoxycorticosterone / Dihydrodeoxycorticosterone: 5α-Dihydrodeoxycorticosterone , izwi kandi nka 21-hydroxy-5α-gutwita-20-imwe , ni progestogene ya endogenous na neurosteroid. Ihindurwamo imisemburo ya adrenal deoxycorticosterone (DOC) na enzyme 5α-reductase yo mu bwoko bwa I. DHDOC ni agoniste wa reseptor ya progesterone, ndetse na moderi nziza ya allosteric modulator ya reseptor ya GABA A , kandi izwiho kugira ingaruka za anticonvulsant.
5% CE% B1-dihydroethisterone / 5α-Dihydroethisterone: 5α-Dihydroethisterone ni metabolite Gikora ya kera abaganga gukoreshwa ariko ubu-yahagaze progestin ethisterone na igerageza no rimwe-marketed imisemburo antineoplastic agent ethynylandrostanediol (HE-3235). Imiterere yabyo ituruka kumiti yababyeyi iterwa na 5α-reductase mumyanya igaragaza enzyme mubwinshi nkumwijima, uruhu, imisatsi, na glande ya prostate. 5α-DHET ifitanye isano ikomeye no kwakira imisemburo ya steroid kandi ishobora kugira uruhare runini mubikorwa byibiyobyabwenge byababyeyi.
5% CE% B1-dihydroethylestrenolone / 5α-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5α-DHNED ), izwi kandi nka 17α-ethyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-ethyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid na metabolite ya norethandrolone yakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNED yerekana kugabanuka kwakirwa na reseptor ya androgene ugereranije na norethandrolone. Kuba hafi ya androgene yakira ni hafi 64% bya norethandrolone.
5% CE% B1-dihydrofluoxymesterone / Dihydrofluoxymesterone: Dihydrofluoxymesterone ni androgene na anabolike steroid (AAS) itigeze igurishwa. Yasuzumwe mu kuvura kanseri y'ibere ku bagore mu bushakashatsi nibura bumwe mu mavuriro mu myaka ya za 70 kandi bugaragaza imikorere isa n'iy'abandi AAS. Umuti ni 5α wagabanutse analogue na metabolite ya fluoxymesterone.
5% CE% B1-dihydrolevonorgestrel / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-dihydromethylnandrolone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-dihydromethylnortestosterone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-dihydronandrolone / 5α-Dihydronandrolone: 5α-Dihydronandrolone nibisanzwe bibaho anabolike - androgeneque steroid (AAS) hamwe na 5α yagabanutse ikomoka kuri nandrolone (19-nortestosterone). Ni metabolite ikomeye ya nandrolone kandi ikorwa muri yo n'ibikorwa bya enzyme 5α-reductase bisa no gushiraho dihydrotestosterone (DHT) ivuye muri testosterone.
5% CE% B1-dihydronorethandrolone / 5α-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5α-DHNED ), izwi kandi nka 17α-ethyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-ethyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid na metabolite ya norethandrolone yakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNED yerekana kugabanuka kwakirwa na reseptor ya androgene ugereranije na norethandrolone. Kuba hafi ya androgene yakira ni hafi 64% bya norethandrolone.
5% CE% B1-dihydronorethindrone / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-dihydronorethisterone / 5α-Dihydronorethisterone: 5α-Dihydronorethisterone ni metabolite ikomeye ya norethisterone (norethindrone). Norethisterone ni progestine hamwe nibindi bikorwa bya andorogène na estrogene. 5α-DHNET ikozwe muri norethisterone na 5α-reductase mu mwijima no mu zindi ngingo.
5% CE% B1-dihydronorgestrel / 5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5α-DHLNG ) ni metabolite ikora ya progestine levonorgestrel ikorwa na 5α-reductase. Ifite hafi kimwe cya gatatu cyumubano wa levonorgestrel kuri progesterone. Bitandukanye na levonorgestrel, uruganda rufite ibikorwa bya progestogenic na antiprogestogenic, bityo rero ikaba ifite progesterone yakira reseptor modulator imeze nkibikorwa byibikorwa. Ibi birasa nikibazo cya norethisterone na 5α-dihydronorethisterone. Usibye reseptor ya progesterone, 5α-DHLNG ikorana na reseptor ya androgene. Ifite isano isa na reseptor ya androgene ugereranije na levonorgestrel, kandi ifite ingaruka za androgeneque nka levonorgestrel na testosterone. 5α-DHLNG yongeye guhindurwa muri 3α, 5α- na 3β, 5α- THLNG , ihuza intege nke na reseptor ya estrogene kandi ifite ibikorwa bya estrogene. Izi metabolite zifatwa nkinshingano zintege nke za estrogeneque ya dosiye nyinshi ya levonorgestrel.
5% CE% B1-dihydronormethandrone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-dihydronormethyltestosterone / 5α-Dihydronormethandrone: 5α-Dihydronormethandrone , izwi kandi nka 17α-methyl-4,5α-dihydro-19-nortestosterone cyangwa nka 17α-methyl-5α-estran-17β-ol-3-imwe , ni androgene / anabolike steroid kandi ishobora kuba metabolite ya normethandrone byakozwe na 5α-reductase. Mu buryo busa na nandrolone hamwe na 5α yagabanijwe na metabolite 5α-dihydronandrolone, 5α-DHNMT yerekana kugabanuka kwinshi kuri reseptor ya androgene ugereranije na normethandrone. Kuba ifitanye isano na reseptor ya androgene ni hafi 33 kugeza 60% bya normethandrone.
5% CE% B1-dihydroprogesterone / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-dihydrotestosterone / Dihydrotestosterone: Dihydrotestosterone ni endogenous androgen igitsina steroid na hormone. Enzyme 5α-reductase itera ishingwa rya DHT kuva testosterone mubice bimwe na bimwe birimo glande ya prostate, vitamine seminal, epididymide, uruhu, imisatsi, umwijima, n'ubwonko. Iyi misemburo ihuza kugabanya C4-5 inshuro ebyiri za testosterone. Ugereranije na testosterone, DHT irakomeye cyane nka agonist ya reseptor ya androgene (AR).
5% CE% B1-dihydrotestosterone 17% CE% B2-undecanoate / Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), izwi kandi nka androstanolone undecanoate cyangwa stanolone undecanoate , ni sintetike ya androgene na anabolike steroid (AAS) itigeze igurishwa. Ni estrogene ester; byumwihariko, ni C17β idasobanutse (undecylate) ester ya dihydrotestosterone (DHT). DHTU ni prodrug ya DHT. Kimwe na testosterone idasobanutse (TU), DHTU irakora kumanwa. Bibaho nkingirakamaro ya metabolite yingirakamaro ya TU. 5α-reductase inhibitor finasteride ifatanije na TU yo mu kanwa nta ngaruka igira ku ihinduka ryambere rya TU muri DHTU cyangwa DHT, birashoboka kubera inzira yihariye ya lymphatique yo kwinjirira. DHTU yo mu kanwa irashobora kwinjizwa na sisitemu ya lymphatike isa na TU, kandi ibi birashobora gusobanura bioavailable yo mu kanwa.
5% CE% B1-dihydrotestosterone 17% CE% B2-undecylate / Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), izwi kandi nka androstanolone undecanoate cyangwa stanolone undecanoate , ni sintetike ya androgene na anabolike steroid (AAS) itigeze igurishwa. Ni estrogene ester; byumwihariko, ni C17β idasobanutse (undecylate) ester ya dihydrotestosterone (DHT). DHTU ni prodrug ya DHT. Kimwe na testosterone idasobanutse (TU), DHTU irakora kumanwa. Bibaho nkingirakamaro ya metabolite yingirakamaro ya TU. 5α-reductase inhibitor finasteride ifatanije na TU yo mu kanwa nta ngaruka igira ku ihinduka ryambere rya TU muri DHTU cyangwa DHT, birashoboka kubera inzira yihariye ya lymphatique yo kwinjirira. DHTU yo mu kanwa irashobora kwinjizwa na sisitemu ya lymphatike isa na TU, kandi ibi birashobora gusobanura bioavailable yo mu kanwa.
5% CE% B1-estran-17% CE% B2-ol-3-umwe / 5α-Dihydronandrolone: 5α-Dihydronandrolone nibisanzwe bibaho anabolike - androgeneque steroid (AAS) hamwe na 5α yagabanutse ikomoka kuri nandrolone (19-nortestosterone). Ni metabolite ikomeye ya nandrolone kandi ikorwa muri yo n'ibikorwa bya enzyme 5α-reductase bisa no gushiraho dihydrotestosterone (DHT) ivuye muri testosterone.
5% CE% B1-gutwita-17% CE% B1-ol-3,20-dione / 5α-Pregnan-17α-ol-3,20-dione: 5α-Pregnan-17α-ol-3,20-dione , izwi kandi nka 17α-hydroxy-dihydroprogesterone ( 17 - OH-DHP ) ni steroid ya endogenous.
5% CE% B1-gutwita-3,20-dione / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-gutwita-3% CE% B1,20% CE% B1-diol / Allopregnanediol: Allopregnanediol , cyangwa 5α-gutwita-3α, 20α-diol , ni metabolite ya endogenous ya progesterone na allopregnanolone hamwe na isomer wa womediediol (5β-gutwita-3α, 20α-diol). Byagaragaye ko bikora nka agonist igice cyurubuga rwa allosteric ya reseptor ya GABA bityo bikaba bishobora kugira uruhare mubinyabuzima nka neurosteroid. Byagaragaye kandi ko ikora nka agonist ya reseptor ya muntu itwite X, nubwo ifite EC 50 irenze gahunda yubunini buri munsi ugereranije nizindi nda zitwite endogène nka gutwita, gutwita, allopregnanedione, na allopregnanolone.
5% CE% B1-inda / Allopregnane: 5α-Pregnane , izwi kandi nka Allopregnane cyangwa nka 10β, 13β-dimethyl-17β-ethyl-5α-gonane , ni steroid hamwe n'ababyeyi bavanga ibintu bitandukanye bikomoka kuri steroid. Nimwe muri epimers yo gutwita, indi ni 5β-inda. Ibikomoka kuri Allopregnane harimo steroide isanzwe ibaho Allopregnanolone, Allopregnanediol, Isopregnanolone, na 5α-Dihydroprogesterone.
5% CE% B1-inda-3,20-dione / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-gutwita-3% CE% B1,17% CE% B1-diol-20-umwe / 5α-Pregnane-3α, 17α-diol-20-imwe: 5α-Pregnane-3α, 17α-diol-20-imwe , izwi kandi nka 17α-hydroxyallopregnanolone ( 17-OH-allo ) ni steroid ya endogenous.
5% CE% B1-inda-3% CE% B1,20% CE% B1-diol / Allopregnanediol: Allopregnanediol , cyangwa 5α-gutwita-3α, 20α-diol , ni metabolite ya endogenous ya progesterone na allopregnanolone hamwe na isomer wa womediediol (5β-gutwita-3α, 20α-diol). Byagaragaye ko bikora nka agonist igice cyurubuga rwa allosteric ya reseptor ya GABA bityo bikaba bishobora kugira uruhare mubinyabuzima nka neurosteroid. Byagaragaye kandi ko ikora nka agonist ya reseptor ya muntu itwite X, nubwo ifite EC 50 irenze gahunda yubunini buri munsi ugereranije nizindi nda zitwite endogène nka gutwita, gutwita, allopregnanedione, na allopregnanolone.
5% CE% B1-gutwita / Allopregnanediol: Allopregnanediol , cyangwa 5α-gutwita-3α, 20α-diol , ni metabolite ya endogenous ya progesterone na allopregnanolone hamwe na isomer wa womediediol (5β-gutwita-3α, 20α-diol). Byagaragaye ko bikora nka agonist igice cyurubuga rwa allosteric ya reseptor ya GABA bityo bikaba bishobora kugira uruhare mubinyabuzima nka neurosteroid. Byagaragaye kandi ko ikora nka agonist ya reseptor ya muntu itwite X, nubwo ifite EC 50 irenze gahunda yubunini buri munsi ugereranije nizindi nda zitwite endogène nka gutwita, gutwita, allopregnanedione, na allopregnanolone.
5% CE% B1-gutwita / 5α-Dihydroprogesterone: 5α-Dihydroprogesterone ni progestogene ya endogenous na neurosteroid ikomatanyirizwa muri progesterone. Nibindi biciriritse muri synthesis ya allopregnanolone na isopregnanolone kuva progesterone.
5% CE% B1-kugabanya / 5α-Kugabanya: 5α-reductase , izwi kandi nka 3-oxo-5α-steroid 4-dehydrogenase , ni enzymes zigira uruhare muri metabolism ya steroid. Bitabira inzira 3 zo guhinduranya: aside aside biosynthesis, androgene na metabolism ya estrogene. Hano hari isozymes eshatu za 5α-reductase, SRD5A1, SRD5A2, na SRD5A3, zitandukanye mubice bitandukanye hamwe nimyaka.
5% CE% B1-kugabanya 2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-kugabanya I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1-kugabanya II / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-kugabanya ibura / 5α-Kugabanya ibura: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1-kugabanya inhibitor / 5α-Kugabanya inhibitor: 5α-Kugabanya inhibitori ( 5-ARIs ), izwi kandi nka dihydrotestosterone ( DHT ) ikumira , ni urwego rwimiti ifite ingaruka za antandrogeneque zikoreshwa cyane cyane mukuvura prostate nini no guta umusatsi. Rimwe na rimwe zikoreshwa mu kuvura imikurire ikabije ku bagore kandi nkigice cyo kuvura imisemburo ku bagore bahindura ibitsina.
5% CE% B1-reductase inhibitor / 5α-Kugabanya inhibitor: 5α-Kugabanya inhibitori ( 5-ARIs ), izwi kandi nka dihydrotestosterone ( DHT ) ikumira , ni urwego rwimiti ifite ingaruka za antandrogeneque zikoreshwa cyane cyane mukuvura prostate nini no guta umusatsi. Rimwe na rimwe zikoreshwa mu kuvura imikurire ikabije ku bagore kandi nkigice cyo kuvura imisemburo ku bagore bahindura ibitsina.
5% CE% B1-kugabanya ubwoko_1 / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1-kugabanya ubwoko_2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-kugabanya ubwoko_2_ibura / 5α-Kugabanya: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1-kugabanya ubwoko_I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1-kugabanya ubwoko_II / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1-kugabanya ubwoko_II_ibura / 5α-Kugabanya: 5α-Kugabanya ibura ni autosomal recessive intersex imiterere iterwa na mutation muri SRD5A2 , gene ikubiyemo enzyme 5α-reductase ubwoko bwa 2. Fenotype ikunze gutera ni pseudovaginal perineoscrotal hypospadias , iboneza ryimyanya ndangagitsina yo hanze yumwana. Mu buryo bumwe, ibonezamiterere riri hagati yimyanya ndangagitsina yumugabo ya fenotipiki, nigitsina gore cyumugore, muburyo no mumiterere. Nuburyo busanzwe bwo kudasobanuka kwimyanya ndangagitsina biterwa no kwanduza abagabo b'ingirabuzima fatizo bitewe n'imiterere itandukanye.
5% CE% B1 Kugabanya_2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1 Kugabanya_I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1 Kugabanya_II / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1 Kugabanya_inhibitor / 5α-Kugabanya inhibitor: 5α-Kugabanya inhibitori ( 5-ARIs ), izwi kandi nka dihydrotestosterone ( DHT ) ikumira , ni urwego rwimiti ifite ingaruka za antandrogeneque zikoreshwa cyane cyane mukuvura prostate nini no guta umusatsi. Rimwe na rimwe zikoreshwa mu kuvura imikurire ikabije ku bagore kandi nkigice cyo kuvura imisemburo ku bagore bahindura ibitsina.
5% CE% B1 Kugabanya_ubwoko_1 / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1 Kugabanya_ubwoko_2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1 Kugabanya_ubwoko_I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.
5% CE% B1 Kugabanya_ubwoko_II / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1 reductase_2 / SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 ni enzyme ko mubantu igizwe na gen SRD5A2 . Nimwe muri isozymes eshatu za 5α-reductase.
5% CE% B1 reductase_I / SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 ni enzyme ko mubantu igizwe na gen SRD5A1 . Nuburyo bumwe muburyo butatu bwa steroid 5α-reductase.