3%C3%973 Eyes_~Sanjiyan_Henjyo~/3×3 Eyes, 3%C3%975/Index card

3% C3% 973 Amaso_ ~ Sanjiyan_Henjyo ~ / 3 × 3 Amaso: 3 × 3 Amaso , avugwa Amaso ya Sazan mu Kiyapani, ni manga yanditse kandi ishushanywa na Yuzo Takada. Manga yakurikiranwe mu kinyamakuru Weekly Young Magazine kuva 1987 kugeza 2002, igera kuri 40 yose. Mu 1993, yatsindiye igihembo cya Kodansha Manga kuri shōnen. Ubusobanuro bw'icyongereza bwasohowe na Dark Horse Comics, ariko bwahagaritswe nyuma yo gusohora umuzingo wa 9 mu 2005.
3% C3% 975 / Ikarita yerekana: Ikarita yerekana ikarita igizwe namakarita yagabanijwe kugeza ku bunini busanzwe, ikoreshwa mu gufata amajwi no kubika umubare muto wamakuru yihariye. Icyegeranyo cyamakarita nkaya akora nka, cyangwa ifasha kurema, indangagaciro yo gushakisha amakuru byihuse. Sisitemu yahimbwe na Carl Linnaeus, ahagana mu 1760.
3% C3% 975 (indirimbo) / Icyumba cya kare: Icyumba cya Square ni alubumu ya mbere ya studio yakozwe numuririmbyi w'indirimbo w'umunyamerika John Mayer, yasohotse bwa mbere ku ya 5 Kamena 2001 yongera gusohoka ku ya 18 Nzeri 2001 na Aware na Columbia Records. Irekuwe, yageze ku mwanya wa 8 kuri Billboard 200 yo muri Amerika kandi yakiriwe neza muri rusange. Yabonye Mayer igihembo cya Grammy Igihembo Cyiza Cyiza Cyabagabo Cyamamare Cyindirimbo imwe "Umubiri wawe ni Igitangaza".
3% C3% A8me Bataille_des_Flanders / Intambara ya Lys (1918): Intambara ya Lys , izwi kandi ku izina rya Kane ya Ypres , yarwanye kuva ku ya 7 kugeza ku ya 29 Mata 1918 kandi yari mu bitero by'Abadage byibasiye Flanders mu gihe cy'Intambara ya Mbere y'Isi Yose. Ubusanzwe byari byateguwe na Jenerali Erich Ludendorff nka Operation George ariko bigabanywa kuri Operation Georgette , hagamijwe gufata Ypres, guhatira ingabo z'Ubwongereza gusubira ku byambu bya Channel no mu ntambara. Mugutegura, gushyira mubikorwa n'ingaruka, Georgette yasaga na Operation Michael, mbere mubitero byimpeshyi.
3% C3% A8me arrondissement, _Paris / Arrondissement ya 3 ya Paris: Arrondissement ya 3 ya Paris nimwe muri 20 arrondissement (uturere) mumurwa mukuru wUbufaransa. Mu gifaransa kivugwa, iyi arrondissement bakunze kuvuga "Troisième" bisobanura "icya gatatu" mu gifaransa. Yashizwemo nka kode ya 75003.
3% C3% A8me temps / 3ème temps: 3e temps ni alubumu ya gatatu ya studio ya Grand Corps Malade. Ikigaragara cyane harimo ubufatanye na Charles Aznavour, umuhanzi ukunzwe wa Fabien Marsaud.
3% CE% B1,17% CE% B2-Etiocholanediol / 3α-Etiocholanediol: 3α-Etiocholanediol , cyangwa etiocholanediol gusa, izwi kandi nka 3α, 5β-androstanediol cyangwa nka etiocholane-3α, 17β-diol , ni etiocholane (5β-androstane) steroid na endogenous metabolite ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka na etiocholanolone.
3% CE% B1,17% CE% B2-etiocholanediol / 3α-Etiocholanediol: 3α-Etiocholanediol , cyangwa etiocholanediol gusa, izwi kandi nka 3α, 5β-androstanediol cyangwa nka etiocholane-3α, 17β-diol , ni etiocholane (5β-androstane) steroid na endogenous metabolite ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka na etiocholanolone.
3% CE% B1,5% CE% B1-Androstanediol / 3α-Androstanediol: 3α-Androstanediol izwi kandi nka 5α-androstane-3α, 17β-diol ndetse rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3α-diol , ni imisemburo ya endogenous steroid na neurosteroid na metabolite ya andorogene nka dihydrotestosterone (DHT).
3% CE% B1,5% CE% B1-THB / Tetrahydrocorticosterone: 3α, 5α-Tetrahydrocorticosterone ( 3α, 5α-THB ), cyangwa tetrahydrocorticosterone gusa, ni imisemburo ya glucocorticoid.
3% CE% B1,5% CE% B1-THCC / Tetrahydrocorticosterone: 3α, 5α-Tetrahydrocorticosterone ( 3α, 5α-THB ), cyangwa tetrahydrocorticosterone gusa, ni imisemburo ya glucocorticoid.
3% CE% B1,5% CE% B1-Tetrahydrocorticosterone / Tetrahydrocorticosterone: 3α, 5α-Tetrahydrocorticosterone ( 3α, 5α-THB ), cyangwa tetrahydrocorticosterone gusa, ni imisemburo ya glucocorticoid.
3% CE% B1,5% CE% B1-androstanediol / 3α-Androstanediol: 3α-Androstanediol izwi kandi nka 5α-androstane-3α, 17β-diol ndetse rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3α-diol , ni imisemburo ya endogenous steroid na neurosteroid na metabolite ya andorogene nka dihydrotestosterone (DHT).
3% CE% B1,5% CE% B1-tetrahydrocorticosterone / Tetrahydrocorticosterone: 3α, 5α-Tetrahydrocorticosterone ( 3α, 5α-THB ), cyangwa tetrahydrocorticosterone gusa, ni imisemburo ya glucocorticoid.
3% CE% B1,5% CE% B1-tetrahydroprogesterone / Allopregnanolone: Allopregnanolone , izwi kandi nka brexanolone, ni steroid isanzwe ikorwa mu bwonko. Numuti , igurishwa mwizina rya Zulresso kandi ikoreshwa mukuvura depression nyuma yo kubyara. Ikoreshwa mugutera inshinge mugihe cyamasaha 60 ikurikiranwa nubuvuzi.
3% CE% B1,5% CE% B2-Androstanediol / 3α-Etiocholanediol: 3α-Etiocholanediol , cyangwa etiocholanediol gusa, izwi kandi nka 3α, 5β-androstanediol cyangwa nka etiocholane-3α, 17β-diol , ni etiocholane (5β-androstane) steroid na endogenous metabolite ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka na etiocholanolone.
3% CE% B1,5% CE% B2-androstanediol / 3α-Etiocholanediol: 3α-Etiocholanediol , cyangwa etiocholanediol gusa, izwi kandi nka 3α, 5β-androstanediol cyangwa nka etiocholane-3α, 17β-diol , ni etiocholane (5β-androstane) steroid na endogenous metabolite ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka na etiocholanolone.
3% CE% B1,7% CE% B1,12% CE% B1-trihydroxy-5% CE% B2-acide cholanic / Acide Cholike: Acide Cholike , izwi kandi nka 3α, 7α, 12α-trihydroxy-5β-cholan-24-oic aside ni aside yibanze ya aside idashobora gushonga mumazi, ni ibintu byera bya kristaline. Umunyu wa acide cholike witwa cholates . Acide Cholike, hamwe na acide chenodeoxycholic, ni imwe muri acide ebyiri zikomeye zakozwe n'umwijima, aho zinjizwa muri cholesterol. Izi aside ebyiri nyamukuru zingana hafi yo kwibanda kubantu. Inkomoko ikozwe muri cholyl-CoA, ihana CoA yayo na glycine, cyangwa taurine, itanga aside glycocholike na taurocholike.
3% CE% B1-Androstanediol / 3α-Androstanediol: 3α-Androstanediol izwi kandi nka 5α-androstane-3α, 17β-diol ndetse rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3α-diol , ni imisemburo ya endogenous steroid na neurosteroid na metabolite ya andorogene nka dihydrotestosterone (DHT).
3% CE% B1-Androstanediol glucuronide / Andurstanediol glucuronide: 3α-Androstanediol glucuronide ( 3α-ADG ) ni metabolite ikomoka kuri andorogene y'abantu; ibice bigira uruhare mugutezimbere no kubungabunga ibiranga igitsina. Ikorwa na glucuronidation ya dihydrotestosterone na testosterone, kandi yatanzwe nkuburyo bwo gupima ibikorwa bya andorogene.
3% CE% B1-Androstenol / Androstenol: Androstenol , izwi kandi nka 5α-androst-16-en-3α-ol , ni feromone ya steroidal na neurosteroid mu bantu no mu yandi matungo y'inyamabere, cyane cyane ingurube. Ifite umunuko uranga impumuro nziza.
3% CE% B1-Dihydroprogesterone / 3α-Dihydroprogesterone: 3α-Dihydroprogesterone ( 3α-DHP ), izwi kandi nka 3α-hydroxyprogesterone , ndetse no gutwita-4-en-3α-ol-20-imwe , ni neurosteroid ya endogenous. Ni biosynthesize na 3α-hydroxysteroid dehydrogenase kuva progesterone. 3α-DHP byagaragaye ko ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor kandi isobanurwa ko ikora nka allopregnanolone kubijyanye niki gikorwa. Ukurikije, ifite ingaruka za anxiolytike mu nyamaswa. 3α-DHP yasanze kandi ibuza gusohora imisemburo itera imisemburo (FSH) ivuye mu mitsi y'imbeba, ikagaragaza imiterere ya antigonadotropique. Bitandukanye nubundi buryo bwinshi bwo kubuza neurosteroide, umusaruro wa 3α-DHP ntuhagarikwa na 5α-reductase inhibitor nka finasteride. Nta makuru yaboneka kubikorwa bya progestogenic ya 3α-DHP guhera 1977. Urwego rwa 5α-DHP rwarabaruwe.
3% CE% B1-Etiocholanediol / 3α-Etiocholanediol: 3α-Etiocholanediol , cyangwa etiocholanediol gusa, izwi kandi nka 3α, 5β-androstanediol cyangwa nka etiocholane-3α, 17β-diol , ni etiocholane (5β-androstane) steroid na endogenous metabolite ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka na etiocholanolone.
3% CE% B1-Hydroxy-5-androsten-17-imwe / Dehydroandrosterone: Dehydroandrosterone ( DHA ), cyangwa 5-dehydroandrosterone ( 5-DHA ), izwi kandi ku izina rya isoandrostenolone , ndetse na androst-5-en-3α-ol-17-imwe , ni imisemburo ya endogene ya androgene steroid. Ni 3α-epimer ya dehydroepiandrosterone hamwe na 5 (6) -yidegenejene na 5α yagabanutse analogue ya androsterone (5α-androstan-3α-ol-17-imwe). DHA ikorerwa kandi ikasohoka muri glande ya adrenal, hamwe nizindi androgene zifite intege nke nka DHEA, androstenediol, na androstenedione.
3% CE% B1-Hydroxy-5% CE% B2-estran-17-umwe / 19-Noretiocholanolone: 19-Noretiocholanolone , izwi kandi nka 5β-estran-3α-ol-17-imwe , ni metabolite ya nandrolone (19-nortestosterone) na bolandione (19-norandrostenedione) ikorwa na 5α-reductase. Ari kurutonde rwibintu bibujijwe n'ikigo cy'isi gishinzwe kurwanya ibiyobyabwenge kuko ari metabolite igaragara ya nandrolone, anabolike-androgeneque steroid (AAS).
3% CE% B1-Hydroxyandrost-5-en-17-umwe / Dehydroandrosterone: Dehydroandrosterone ( DHA ), cyangwa 5-dehydroandrosterone ( 5-DHA ), izwi kandi ku izina rya isoandrostenolone , ndetse na androst-5-en-3α-ol-17-imwe , ni imisemburo ya endogene ya androgene steroid. Ni 3α-epimer ya dehydroepiandrosterone hamwe na 5 (6) -yidegenejene na 5α yagabanutse analogue ya androsterone (5α-androstan-3α-ol-17-imwe). DHA ikorerwa kandi ikasohoka muri glande ya adrenal, hamwe nizindi androgene zifite intege nke nka DHEA, androstenediol, na androstenedione.
3% CE% B1-Hydroxyprogesterone / 3α-Dihydroprogesterone: 3α-Dihydroprogesterone ( 3α-DHP ), izwi kandi nka 3α-hydroxyprogesterone , ndetse no gutwita-4-en-3α-ol-20-imwe , ni neurosteroid ya endogenous. Ni biosynthesize na 3α-hydroxysteroid dehydrogenase kuva progesterone. 3α-DHP byagaragaye ko ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor kandi isobanurwa ko ikora nka allopregnanolone kubijyanye niki gikorwa. Ukurikije, ifite ingaruka za anxiolytike mu nyamaswa. 3α-DHP yasanze kandi ibuza gusohora imisemburo itera imisemburo (FSH) ivuye mu mitsi y'imbeba, ikagaragaza imiterere ya antigonadotropique. Bitandukanye nubundi buryo bwinshi bwo kubuza neurosteroide, umusaruro wa 3α-DHP ntuhagarikwa na 5α-reductase inhibitor nka finasteride. Nta makuru yaboneka kubikorwa bya progestogenic ya 3α-DHP guhera 1977. Urwego rwa 5α-DHP rwarabaruwe.
3% CE% B1-Hydroxysteroid dehydrogenase / 3α-Hydroxysteroid dehydrogenase: 3α-Hydroxysteroid dehydrogenase ni enzyme ko mu bantu igizwe na gen AKR1C4 . Birazwi ko ari nkenerwa muguhuza endogenous neurosteroids allopregnanolone, THDOC, na 3α-androstanediol. Birazwi kandi ko bihindura ihinduka rya 3α-androstanediol (5α-androstane-3α, 17β-diol) kuri dihydrotestosterone naho ubundi.
3% CE% B1-Hydroxysteroid dehydrogenase / 3α-Hydroxysteroid dehydrogenase: 3α-Hydroxysteroid dehydrogenase ni enzyme ko mu bantu igizwe na gen AKR1C4 . Birazwi ko ari nkenerwa muguhuza endogenous neurosteroids allopregnanolone, THDOC, na 3α-androstanediol. Birazwi kandi ko bihindura ihinduka rya 3α-androstanediol (5α-androstane-3α, 17β-diol) kuri dihydrotestosterone naho ubundi.
3% CE% B1-Hydroxysteroid oxidoreductase / 3α-Hydroxysteroid dehydrogenase: 3α-Hydroxysteroid dehydrogenase ni enzyme ko mu bantu igizwe na gen AKR1C4 . Birazwi ko ari nkenerwa muguhuza endogenous neurosteroids allopregnanolone, THDOC, na 3α-androstanediol. Birazwi kandi ko bihindura ihinduka rya 3α-androstanediol (5α-androstane-3α, 17β-diol) kuri dihydrotestosterone naho ubundi.
3% CE% B1-Hydroxytibolone / 3α-Hydroxytibolone: 3α-Hydroxytibolone ni intungamubiri ya steroidal estrogene itigeze igurishwa. Hamwe na 3β-hydroxytibolone na δ 4 -tibolone , ni metabolite ikomeye ya tibolone, na 3α-hydroxytibolone na 3β-hydroxytibolone batekereza ko aribo bashinzwe ibikorwa bya estrogeneque ya tibolone.
3% CE% B1-Mannobiose / 3α-Mannobiose: 3α-Mannobiose ni disaccharide igizwe na molekile ebyiri za mannose zahujwe na α (1 → 3) glycosidic.
3% CE% B1-androstanediol / 3α-Androstanediol: 3α-Androstanediol izwi kandi nka 5α-androstane-3α, 17β-diol ndetse rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3α-diol , ni imisemburo ya endogenous steroid na neurosteroid na metabolite ya andorogene nka dihydrotestosterone (DHT).
3% CE% B1-androstanediol glucuronide / Andurstanediol glucuronide: 3α-Androstanediol glucuronide ( 3α-ADG ) ni metabolite ikomoka kuri andorogene y'abantu; ibice bigira uruhare mugutezimbere no kubungabunga ibiranga igitsina. Ikorwa na glucuronidation ya dihydrotestosterone na testosterone, kandi yatanzwe nkuburyo bwo gupima ibikorwa bya andorogene.
3% CE% B1-androstenol / Androstenol: Androstenol , izwi kandi nka 5α-androst-16-en-3α-ol , ni feromone ya steroidal na neurosteroid mu bantu no mu yandi matungo y'inyamabere, cyane cyane ingurube. Ifite umunuko uranga impumuro nziza.
3% CE% B1-dihydroprogesterone / 3α-Dihydroprogesterone: 3α-Dihydroprogesterone ( 3α-DHP ), izwi kandi nka 3α-hydroxyprogesterone , ndetse no gutwita-4-en-3α-ol-20-imwe , ni neurosteroid ya endogenous. Ni biosynthesize na 3α-hydroxysteroid dehydrogenase kuva progesterone. 3α-DHP byagaragaye ko ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor kandi isobanurwa ko ikora nka allopregnanolone kubijyanye niki gikorwa. Ukurikije, ifite ingaruka za anxiolytike mu nyamaswa. 3α-DHP yasanze kandi ibuza gusohora imisemburo itera imisemburo (FSH) ivuye mu mitsi y'imbeba, ikagaragaza imiterere ya antigonadotropique. Bitandukanye nubundi buryo bwinshi bwo kubuza neurosteroide, umusaruro wa 3α-DHP ntuhagarikwa na 5α-reductase inhibitor nka finasteride. Nta makuru yaboneka kubikorwa bya progestogenic ya 3α-DHP guhera 1977. Urwego rwa 5α-DHP rwarabaruwe.
3% CE% B1-etiocholanediol / 3α-Etiocholanediol: 3α-Etiocholanediol , cyangwa etiocholanediol gusa, izwi kandi nka 3α, 5β-androstanediol cyangwa nka etiocholane-3α, 17β-diol , ni etiocholane (5β-androstane) steroid na endogenous metabolite ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka na etiocholanolone.
3% CE% B1-hydroxy-5-androsten-17-imwe / Dehydroandrosterone: Dehydroandrosterone ( DHA ), cyangwa 5-dehydroandrosterone ( 5-DHA ), izwi kandi ku izina rya isoandrostenolone , ndetse na androst-5-en-3α-ol-17-imwe , ni imisemburo ya endogene ya androgene steroid. Ni 3α-epimer ya dehydroepiandrosterone hamwe na 5 (6) -yidegenejene na 5α yagabanutse analogue ya androsterone (5α-androstan-3α-ol-17-imwe). DHA ikorerwa kandi ikasohoka muri glande ya adrenal, hamwe nizindi androgene zifite intege nke nka DHEA, androstenediol, na androstenedione.
3% CE% B1-hydroxy-5% CE% B2-estran-17-umwe / 19-Noretiocholanolone: 19-Noretiocholanolone , izwi kandi nka 5β-estran-3α-ol-17-imwe , ni metabolite ya nandrolone (19-nortestosterone) na bolandione (19-norandrostenedione) ikorwa na 5α-reductase. Ari kurutonde rwibintu bibujijwe n'ikigo cy'isi gishinzwe kurwanya ibiyobyabwenge kuko ari metabolite igaragara ya nandrolone, anabolike-androgeneque steroid (AAS).
3% CE% B1-hydroxyandrost-5-en-17-umwe / Dehydroandrosterone: Dehydroandrosterone ( DHA ), cyangwa 5-dehydroandrosterone ( 5-DHA ), izwi kandi ku izina rya isoandrostenolone , ndetse na androst-5-en-3α-ol-17-imwe , ni imisemburo ya endogene ya androgene steroid. Ni 3α-epimer ya dehydroepiandrosterone hamwe na 5 (6) -yidegenejene na 5α yagabanutse analogue ya androsterone (5α-androstan-3α-ol-17-imwe). DHA ikorerwa kandi ikasohoka muri glande ya adrenal, hamwe nizindi androgene zifite intege nke nka DHEA, androstenediol, na androstenedione.
3% CE% B1-hydroxyprogesterone / 3α-Dihydroprogesterone: 3α-Dihydroprogesterone ( 3α-DHP ), izwi kandi nka 3α-hydroxyprogesterone , ndetse no gutwita-4-en-3α-ol-20-imwe , ni neurosteroid ya endogenous. Ni biosynthesize na 3α-hydroxysteroid dehydrogenase kuva progesterone. 3α-DHP byagaragaye ko ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor kandi isobanurwa ko ikora nka allopregnanolone kubijyanye niki gikorwa. Ukurikije, ifite ingaruka za anxiolytike mu nyamaswa. 3α-DHP yasanze kandi ibuza gusohora imisemburo itera imisemburo (FSH) ivuye mu mitsi y'imbeba, ikagaragaza imiterere ya antigonadotropique. Bitandukanye nubundi buryo bwinshi bwo kubuza neurosteroide, umusaruro wa 3α-DHP ntuhagarikwa na 5α-reductase inhibitor nka finasteride. Nta makuru yaboneka kubikorwa bya progestogenic ya 3α-DHP guhera 1977. Urwego rwa 5α-DHP rwarabaruwe.
3% CE% B1-hydroxysteroid dehydrogenase / 3α-Hydroxysteroid dehydrogenase: 3α-Hydroxysteroid dehydrogenase ni enzyme ko mu bantu igizwe na gen AKR1C4 . Birazwi ko ari nkenerwa muguhuza endogenous neurosteroids allopregnanolone, THDOC, na 3α-androstanediol. Birazwi kandi ko bihindura ihinduka rya 3α-androstanediol (5α-androstane-3α, 17β-diol) kuri dihydrotestosterone naho ubundi.
3% CE% B1-hydroxysteroid dehydrogenase_ubwoko_3 / AKR1C2: Aldo-keto reductase umuryango 1 umunyamuryango C2 , uzwi kandi nka aside aside ihuza poroteyine , 3α-hydroxysteroid dehydrogenase yo mu bwoko bwa 3 , na dihydrodiol dehydrogenase yo mu bwoko bwa 2 , ni enzyme iba mu bantu igizwe na gen AKR1C2 .
3% CE% B1-hydroxysteroid oxidoreductase / 3α-Hydroxysteroid dehydrogenase: 3α-Hydroxysteroid dehydrogenase ni enzyme ko mu bantu igizwe na gen AKR1C4 . Birazwi ko ari nkenerwa muguhuza endogenous neurosteroids allopregnanolone, THDOC, na 3α-androstanediol. Birazwi kandi ko bihindura ihinduka rya 3α-androstanediol (5α-androstane-3α, 17β-diol) kuri dihydrotestosterone naho ubundi.
3% CE% B1-hydroxytibolone / 3α-Hydroxytibolone: 3α-Hydroxytibolone ni intungamubiri ya steroidal estrogene itigeze igurishwa. Hamwe na 3β-hydroxytibolone na δ 4 -tibolone , ni metabolite ikomeye ya tibolone, na 3α-hydroxytibolone na 3β-hydroxytibolone batekereza ko aribo bashinzwe ibikorwa bya estrogeneque ya tibolone.
3% CE% B2,16% CE% B1-Dihydroxy-5-androstene / Cetadiol: Cetadiol , izwi kandi nka androst-5-ene-3β, 16α-diol , ni ibiyobyabwenge bivugwa ko ari "steroid tranquilizer" byakorewe iperereza muri make nk'umuti w'ubusinzi mu myaka ya za 1950. Ni androstane steroid na analogue ya 5-androstenediol (androst-5-ene-3β, 17β-diol) na 16α-hydroxy-DHEA (androst-5-ene-3β, 16α-diol-17-imwe), ariko yerekanye nta gikorwa cya androgene cyangwa myotrophique muri bioassay yinyamaswa. Uyu muti wavuzwe mu 1956 kandi wiga kugeza 1958.
3% CE% B2,16% CE% B1-Dihydroxyandrost-5-ene / Cetadiol: Cetadiol , izwi kandi nka androst-5-ene-3β, 16α-diol , ni ibiyobyabwenge bivugwa ko ari "steroid tranquilizer" byakorewe iperereza muri make nk'umuti w'ubusinzi mu myaka ya za 1950. Ni androstane steroid na analogue ya 5-androstenediol (androst-5-ene-3β, 17β-diol) na 16α-hydroxy-DHEA (androst-5-ene-3β, 16α-diol-17-imwe), ariko yerekanye nta gikorwa cya androgene cyangwa myotrophique muri bioassay yinyamaswa. Uyu muti wavuzwe mu 1956 kandi wiga kugeza 1958.
3% CE% B2,5% CE% B1-Androstanediol / 3β-Androstanediol: 3β-Androstanediol , izwi kandi nka 5α-androstane-3β, 17β-diol , kandi rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3β-diol , ni imisemburo ya endogenous steroid na metabolite ya androgene nka dehydroepiandrosterone (DHEA) na dihydrotestosterone (DHT).
3% CE% B2,5% CE% B1-Tetrahydroprogesterone / Isopregnanolone: Isopregnanolone , izwi kandi ku izina rya isoallopregnanolone na epiallopregnanolone , ndetse na sepranolone ( INN ), kandi nka 3β-hydroxy-5α-gutwita-20-umwe cyangwa 3β, 5α-tetrahydroprogesterone ( 3β, 5α-THP ), ni neurosteroid na endogenous neurosteroid na a karemano 3β-epimer ya allopregnanolone. Byaravuzwe ko ikora nka subunit-selitifike mbi ya allosteric modulator ya GABA A yakira , kandi ikarwanya inyamaswa n'abantu bamwe ariko siko bose ba GABA A reseptor-medrated medrated of allopregnanolone, nka anesthesia, sedation, ndetse no kugabanya saccadic kugenda kw'amaso, ariko kutiga ubumuga. Isopregnanolone nta ngaruka za hormone kandi bigaragara ko nta ngaruka igira kuri GABA A reseptor yonyine; ihitamo kurwanya allopregnanolone kandi ntabwo ihindura ingaruka zubundi bwoko bwa GABA A reseptor nziza ya allosteric modulator nka benzodiazepine cyangwa barbiturates.
3% CE% B2,5% CE% B1-androstanediol / 3β-Androstanediol: 3β-Androstanediol , izwi kandi nka 5α-androstane-3β, 17β-diol , kandi rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3β-diol , ni imisemburo ya endogenous steroid na metabolite ya androgene nka dehydroepiandrosterone (DHEA) na dihydrotestosterone (DHT).
3% CE% B2,5% CE% B1-tetrahydroprogesterone / Isopregnanolone: Isopregnanolone , izwi kandi ku izina rya isoallopregnanolone na epiallopregnanolone , ndetse na sepranolone ( INN ), kandi nka 3β-hydroxy-5α-gutwita-20-umwe cyangwa 3β, 5α-tetrahydroprogesterone ( 3β, 5α-THP ), ni neurosteroid na endogenous neurosteroid na a karemano 3β-epimer ya allopregnanolone. Byaravuzwe ko ikora nka subunit-selitifike mbi ya allosteric modulator ya GABA A yakira , kandi ikarwanya inyamaswa n'abantu bamwe ariko siko bose ba GABA A reseptor-medrated medrated of allopregnanolone, nka anesthesia, sedation, ndetse no kugabanya saccadic kugenda kw'amaso, ariko kutiga ubumuga. Isopregnanolone nta ngaruka za hormone kandi bigaragara ko nta ngaruka igira kuri GABA A reseptor yonyine; ihitamo kurwanya allopregnanolone kandi ntabwo ihindura ingaruka zubundi bwoko bwa GABA A reseptor nziza ya allosteric modulator nka benzodiazepine cyangwa barbiturates.
3% CE% B2,5% CE% B2-Androstanediol / 3β-Etiocholanediol: 3β-Etiocholanediol , cyangwa epietiocholanediol , izwi kandi nka 3β, 5β-androstanediol cyangwa nka etiocholane-3β, 17β-diol , ni etiocholane (5β-androstane) steroid na metabolite ya endogenous ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka epietiocholanolone.
3% CE% B2,5% CE% B2-androstanediol / 3β-Etiocholanediol: 3β-Etiocholanediol , cyangwa epietiocholanediol , izwi kandi nka 3β, 5β-androstanediol cyangwa nka etiocholane-3β, 17β-diol , ni etiocholane (5β-androstane) steroid na metabolite ya endogenous ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka epietiocholanolone.
3% CE% B2,7% CE% B1-dihydroxyandrost-4-ene-17-umwe / 7α-Hydroxy-DHEA: 7α-Hydroxydehydroepiandrosterone, uzwi 3β, 7α-dihydroxyandrost-4-Ene-17-umwe, ni endogenous, bisanzwe biriko steroid kandi metabolite nyamukuru dehydroepiandrosterone (DHEA) ko azaremerwa by CYP7B1 mu dupapuro nka prostate ku kurusanga no na CYP3A4 mu mwijima. Inzira nyamukuru yo guhinduranya DHEA hanze yumwijima ni 7-hydroxylation muri 7α-OH-DHEA na 7β-OH-DHEA. 7α-OH-DHEA ifite intege nke za estrogeneque, ihitamo gukora reseptor ya estrogene ERβ. Mubyongeyeho, 7α-OH-DHEA irashobora kuba nyirabayazana w'ingaruka zizwi za antiglucocorticoid ya DHEA.
3% CE% B2,7% CE% B2-dihydroxyandrost-4-ene-17-umwe / 7β-Hydroxy-DHEA: 7β-Hydroxydehydroepiandrosterone , izwi kandi nka 3β, 7β-dihydroxyandrost-4-ene-17-imwe , ni endogenous, isanzwe ibaho steroid na metabolite ya dehydroepiandrosterone (DHEA). Inzira nyamukuru yo guhinduranya DHEA hanze yumwijima ni 7-hydroxylation muri 7α-OH-DHEA na 7β-OH-DHEA. 7β-OH-DHEA ifite intege nke zo kurwanya antestrogeneque, ihitamo kurwanya reseptor ya estrogene ERβ.
3% CE% B2- (2- (6-Methoxynaphthyl)) - 8-methyl-2% CE% B1- (propanoyl) -nortropane / 2α- (Propanoyl) -3β- (2- (6-mikorerexynaphthyl)) - - tropane: 2α- (Propanoyl) -3β- (2-) -tropane cyangwa WF-33 ni analogue ya kokayine. Hamwe na WF-23 izindi "2-naphthyl" analogue ya kokayine, ifatwa nkimbaraga zikomeye za WF zikurikirana kokayine.
3% CE% B2- (2- (6-mikorerexynaphthyl)) - 8-methyl-2% CE% B1- (propanoyl) -nortropane / 2α- (Propanoyl) -3β- (2- (6-mikorerexynaphthyl)) - tropane: 2α- (Propanoyl) -3β- (2-) -tropane cyangwa WF-33 ni analogue ya kokayine. Hamwe na WF-23 izindi "2-naphthyl" analogue ya kokayine, ifatwa nkimbaraga zikomeye za WF zikurikirana kokayine.
3% CE% B2- (4% 27-Chlorophenyl) -2% CE% B2- (3% 27-fenylisoxazol-5% 27-yl) tropane / RTI-177: RTI (- 4229 ) -177 numuti utera imbaraga ukomoka mumuryango wa fenyltropane, ukora nka DRI ufite micromolar ifitanye isano na SERT. RTI-177 ifite igihe kirekire kidasanzwe cyibikorwa byamasaha 20 cyangwa arenga, birebire cyane kurenza ibice bifitanye isano na RTI-336 aho itandukaniye mumiterere ya molekile gusa iyo hatabayeho itsinda rya p- methyl.
3% CE% B2- (4% 27-chlorophenyl) -2% CE% B2- (3% 27-fenylisoxazol-5% 27-yl) tropane / RTI-177: RTI (- 4229 ) -177 numuti utera imbaraga ukomoka mumuryango wa fenyltropane, ukora nka DRI ufite micromolar ifitanye isano na SERT. RTI-177 ifite igihe kirekire kidasanzwe cyibikorwa byamasaha 20 cyangwa arenga, birebire cyane kurenza ibice bifitanye isano na RTI-336 aho itandukaniye mumiterere ya molekile gusa iyo hatabayeho itsinda rya p- methyl.
3% CE% B2-Androsta-4,16-dien-3-ol / 4-Androstadienol: 4-Androstadienol , izwi kandi nka 4,16-androstadien-3β-ol , ni ferine irimo gutunganywa na VistaGen Therapeutics, Inc. muburyo bwo gutera amazuru ( PRN ) kugirango bivure bikabije indwara ziterwa no guhangayika. Harimo kandi gukorwaho iperereza na VistaGen Therapeutics yo kuvura indwara rusange yo guhangayika (GAD) hamwe n'ihungabana ry'ihungabana (PTSD) Ferine ni isomer ihagaze kuri ferogenone ya endogenous androstadienol. Kugeza muri 2020, iri mu cyiciro cya III cy'amavuriro kubibazo byo guhangayika.
3% CE% B2-Androstanediol / 3β-Androstanediol: 3β-Androstanediol , izwi kandi nka 5α-androstane-3β, 17β-diol , kandi rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3β-diol , ni imisemburo ya endogenous steroid na metabolite ya androgene nka dehydroepiandrosterone (DHEA) na dihydrotestosterone (DHT).
3% CE% B2-Androstenol / 3β-Androstenol: 3β-Androstenol , izwi kandi nka 5α-androst-16-en-3β-ol , ni feromone y'inyamabere isanzwe ibaho izwiho kuba mu bantu ningurube. Byatekerejweho kugira uruhare mumpumuro nziza. Ikorwa muri androstenone ikoresheje enzyme 3β-hydroxysteroid dehydrogenase. Bitandukanye na C3α epimer yayo 3α-androstenol, 3β-androstenol yerekana ko nta mbaraga za GABA A reseptor cyangwa ibikorwa bya anticonvulsant.
3% CE% B2-Cyclopentyl propionate_of_megestrol_acetate / Cymegesolate: Cymegesolate , izwi kandi nka cypionyl megestrol acetate cyangwa nka megestrol acetate 3β-cypionate , ni imiti ya progestine itigeze igurishwa. Yatunganijwe mu Bushinwa mu mpera za za 70 no mu ntangiriro kugeza hagati ya 1980 kugira ngo ikoreshwe mu kuboneza urubyaro. Imiti yakozwe ku kigero cya mg 50-100 ifatanije na "trace" ya 0,25-0.5 mg quinestrol nk'igihe kirekire, rimwe mu kwezi ikomatanya imiti yo kuboneza urubyaro. Ubu buryo bwakorewe ubushakashatsi ku bagore 1,213 mu gihe cy'imihango 9,651, hamwe no kuboneza urubyaro birenga 99.13% kandi "ni bike cyane." Ku kigero kinini, cyerekanaga igipimo cya anovulation kingana na 60% gusa, ahubwo gihuza ingaruka zacyo zo kuboneza urubyaro hakoreshejwe ingaruka zirwanya anti-implantation.
3% CE% B2-Cyclopentylpropionate ya_megestrol_acetate / Cymegesolate: Cymegesolate , izwi kandi nka cypionyl megestrol acetate cyangwa nka megestrol acetate 3β-cypionate , ni imiti ya progestine itigeze igurishwa. Yatunganijwe mu Bushinwa mu mpera za za 70 no mu ntangiriro kugeza hagati ya 1980 kugira ngo ikoreshwe mu kuboneza urubyaro. Imiti yakozwe ku kigero cya mg 50-100 ifatanije na "trace" ya 0,25-0.5 mg quinestrol nk'igihe kirekire, rimwe mu kwezi ikomatanya imiti yo kuboneza urubyaro. Ubu buryo bwakorewe ubushakashatsi ku bagore 1,213 mu gihe cy'imihango 9,651, hamwe no kuboneza urubyaro birenga 99.13% kandi "ni bike cyane." Ku kigero kinini, cyerekanaga igipimo cya anovulation kingana na 60% gusa, ahubwo gihuza ingaruka zacyo zo kuboneza urubyaro hakoreshejwe ingaruka zirwanya anti-implantation.
3% CE% B2-Cypionate ya_megestrol_acetate / Cymegesolate: Cymegesolate , izwi kandi nka cypionyl megestrol acetate cyangwa nka megestrol acetate 3β-cypionate , ni imiti ya progestine itigeze igurishwa. Yatunganijwe mu Bushinwa mu mpera za za 70 no mu ntangiriro kugeza hagati ya 1980 kugira ngo ikoreshwe mu kuboneza urubyaro. Imiti yakozwe ku kigero cya mg 50-100 ifatanije na "trace" ya 0,25-0.5 mg quinestrol nk'igihe kirekire, rimwe mu kwezi ikomatanya imiti yo kuboneza urubyaro. Ubu buryo bwakorewe ubushakashatsi ku bagore 1,213 mu gihe cy'imihango 9,651, hamwe no kuboneza urubyaro birenga 99.13% kandi "ni bike cyane." Ku kigero kinini, cyerekanaga igipimo cya anovulation kingana na 60% gusa, ahubwo gihuza ingaruka zacyo zo kuboneza urubyaro hakoreshejwe ingaruka zirwanya anti-implantation.
3% CE% B2-Dihydroprogesterone / 3β-Dihydroprogesterone: 3β-Dihydroprogesterone ( 3β-DHP ), izwi kandi nka 3β-hydroxyprogesterone , cyangwa inda-4-en-3β-ol-20-imwe , ni steroid endogenous. Ni biosynthesize na 3β-hydroxysteroid dehydrogenase ikomoka kuri progesterone. Bitandukanye na 3α-dihydroprogesterone (3α-DHP), 3β-DHP ntabwo ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor , ibyo bikaba bihuye nuko izindi 3β-hydroxylated progesterone metabolite nka isopregnanolone na epipregnanolone nayo idakora nka potentiator ziyi reseptor ahubwo ikabuza kimwe no guhindura ingaruka za potentiator nka allopregnanolone. 3β-DHP byavuzwe ko ifite imbaraga zingana na progesterone muri bioassay yibikorwa bya progestogenic, mugihe 3α-DHP itigeze isuzumwa.
3% CE% B2-Etiocholanediol / 3β-Etiocholanediol: 3β-Etiocholanediol , cyangwa epietiocholanediol , izwi kandi nka 3β, 5β-androstanediol cyangwa nka etiocholane-3β, 17β-diol , ni etiocholane (5β-androstane) steroid na metabolite ya endogenous ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka epietiocholanolone.
3% CE% B2-HSD / 3β-Hydroxysteroid dehydrogenase: 3β-Hydroxysteroid dehydrogenase / Δ 5-4 isomerase ( 3β-HSD ) ni umusemburo utera biosynthesis ya steroid progesterone kuva kuri pregnenolone, 17α-hydroxyprogesterone kuva 17α-hydroxypregnenolone, na androstenedione kuva dehydroepiandrosterone (DHEA). Ni enzyme yonyine mumuhanda wa adrenal ya synthesis ya corticosteroid itari mubanyamuryango ba cytochrome P450. Iraboneka kandi mubindi bice bitanga steroid, harimo intanga ngore, testis na plasita. Mu bantu, hariho isozymes ebyiri 3β-HSD zashyizweho na gen ya HSD3B1 na HSD3B2.
3% CE% B2-HSD2 / HSD3B2: HSD3B2 ni gene yumuntu igizwe na 3beta-hydroxysteroid dehydrogenase / delta (5) -delta (4) isomerase ubwoko bwa II cyangwa hydroxy-delta-5-steroid dehydrogenase, 3 beta- na steroid delta-isomerase 2 . Igaragarira cyane cyane mubice bya steroidogenic kandi ni ngombwa mugukora imisemburo ya steroid. Ibidasanzwe bigaragara ni insimburangingo, aho HSD3B1 ari ingenzi kubyara progesterone niyi tissue.
3% CE% B2-HSD 2 / HSD3B2: HSD3B2 ni gene yumuntu igizwe na 3beta-hydroxysteroid dehydrogenase / delta (5) -delta (4) isomerase ubwoko bwa II cyangwa hydroxy-delta-5-steroid dehydrogenase, 3 beta- na steroid delta-isomerase 2 . Igaragarira cyane cyane mubice bya steroidogenic kandi ni ngombwa mugukora imisemburo ya steroid. Ibidasanzwe bigaragara ni insimburangingo, aho HSD3B1 ari ingenzi kubyara progesterone niyi tissue.
3% CE% B2-Hydoxy-5% CE% B1-gutwita-20-umwe / Isopregnanolone: Isopregnanolone , izwi kandi ku izina rya isoallopregnanolone na epiallopregnanolone , ndetse na sepranolone ( INN ), kandi nka 3β-hydroxy-5α-gutwita-20-umwe cyangwa 3β, 5α-tetrahydroprogesterone ( 3β, 5α-THP ), ni neurosteroid na endogenous neurosteroid na a karemano 3β-epimer ya allopregnanolone. Byaravuzwe ko ikora nka subunit-selitifike mbi ya allosteric modulator ya GABA A yakira , kandi ikarwanya inyamaswa n'abantu bamwe ariko siko bose ba GABA A reseptor-medrated medrated of allopregnanolone, nka anesthesia, sedation, ndetse no kugabanya saccadic kugenda kw'amaso, ariko kutiga ubumuga. Isopregnanolone nta ngaruka za hormone kandi bigaragara ko nta ngaruka igira kuri GABA A reseptor yonyine; ihitamo kurwanya allopregnanolone kandi ntabwo ihindura ingaruka zubundi bwoko bwa GABA A reseptor nziza ya allosteric modulator nka benzodiazepine cyangwa barbiturates.
3% CE% B2-Hydroxypregn-4-en-20-umwe / 3β-Dihydroprogesterone: 3β-Dihydroprogesterone ( 3β-DHP ), izwi kandi nka 3β-hydroxyprogesterone , cyangwa inda-4-en-3β-ol-20-imwe , ni steroid endogenous. Ni biosynthesize na 3β-hydroxysteroid dehydrogenase ikomoka kuri progesterone. Bitandukanye na 3α-dihydroprogesterone (3α-DHP), 3β-DHP ntabwo ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor , ibyo bikaba bihuye nuko izindi 3β-hydroxylated progesterone metabolite nka isopregnanolone na epipregnanolone nayo idakora nka potentiator ziyi reseptor ahubwo ikabuza kimwe no guhindura ingaruka za potentiator nka allopregnanolone. 3β-DHP byavuzwe ko ifite imbaraga zingana na progesterone muri bioassay yibikorwa bya progestogenic, mugihe 3α-DHP itigeze isuzumwa.
3% CE% B2-Hydroxyprogesterone / 3β-Dihydroprogesterone: 3β-Dihydroprogesterone ( 3β-DHP ), izwi kandi nka 3β-hydroxyprogesterone , cyangwa inda-4-en-3β-ol-20-imwe , ni steroid endogenous. Ni biosynthesize na 3β-hydroxysteroid dehydrogenase ikomoka kuri progesterone. Bitandukanye na 3α-dihydroprogesterone (3α-DHP), 3β-DHP ntabwo ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor , ibyo bikaba bihuye nuko izindi 3β-hydroxylated progesterone metabolite nka isopregnanolone na epipregnanolone nayo idakora nka potentiator ziyi reseptor ahubwo ikabuza kimwe no guhindura ingaruka za potentiator nka allopregnanolone. 3β-DHP byavuzwe ko ifite imbaraga zingana na progesterone muri bioassay yibikorwa bya progestogenic, mugihe 3α-DHP itigeze isuzumwa.
3% CE% B2-Hydroxysteroid dehydrogenase / 3β-Hydroxysteroid dehydrogenase: 3β-Hydroxysteroid dehydrogenase / Δ 5-4 isomerase ( 3β-HSD ) ni umusemburo utera biosynthesis ya steroid progesterone kuva kuri pregnenolone, 17α-hydroxyprogesterone kuva 17α-hydroxypregnenolone, na androstenedione kuva dehydroepiandrosterone (DHEA). Ni enzyme yonyine mumuhanda wa adrenal ya synthesis ya corticosteroid itari mubanyamuryango ba cytochrome P450. Iraboneka kandi mubindi bice bitanga steroid, harimo intanga ngore, testis na plasita. Mu bantu, hariho isozymes ebyiri 3β-HSD zashyizweho na gen ya HSD3B1 na HSD3B2.
3% CE% B2-Hydroxysteroid dehydrogenase_2 / HSD3B2: HSD3B2 ni gene yumuntu igizwe na 3beta-hydroxysteroid dehydrogenase / delta (5) -delta (4) isomerase ubwoko bwa II cyangwa hydroxy-delta-5-steroid dehydrogenase, 3 beta- na steroid delta-isomerase 2 . Igaragarira cyane cyane mubice bya steroidogenic kandi ni ngombwa mugukora imisemburo ya steroid. Ibidasanzwe bigaragara ni insimburangingo, aho HSD3B1 ari ingenzi kubyara progesterone niyi tissue.
3% CE% B2-Hydroxysteroid dehydrogenase_2_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-Hydroxysteroid dehydrogenase_II_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-Hydroxysteroid dehydrogenase_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-Hydroxysteroid dehydrogenase_ubwoko_2_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-Hydroxysteroid dehydrogenase_ubwoko_II_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-Hydroxysteroid dehydrogenase / 3β-Hydroxysteroid dehydrogenase: 3β-Hydroxysteroid dehydrogenase / Δ 5-4 isomerase ( 3β-HSD ) ni umusemburo utera biosynthesis ya steroid progesterone kuva kuri pregnenolone, 17α-hydroxyprogesterone kuva 17α-hydroxypregnenolone, na androstenedione kuva dehydroepiandrosterone (DHEA). Ni enzyme yonyine mumuhanda wa adrenal ya synthesis ya corticosteroid itari mubanyamuryango ba cytochrome P450. Iraboneka kandi mubindi bice bitanga steroid, harimo intanga ngore, testis na plasita. Mu bantu, hariho isozymes ebyiri 3β-HSD zashyizweho na gen ya HSD3B1 na HSD3B2.
3% CE% B2-Hydroxytibolone / 3β-Hydroxytibolone: 3β-Hydroxytibolone ni estrogene ya steroidal steroidal itigeze igurishwa. Hamwe na 3α-hydroxytibolone na δ 4 -tibolone , ni metabolite ikomeye ya tibolone, na 3α-hydroxytibolone na 3β-hydroxytibolone batekereza ko aribo bashinzwe ibikorwa bya estrogeneque ya tibolone.
3% CE% B2-Methoxypregnenolone / 3β-Methoxypregnenolone: 3β-Methoxypregnenolone , cyangwa inda 3β-methyl ether , izwi kandi nka 3β-mikorerexypregn-5-en-20-imwe , ni sintetike ya neuroactive steroid kandi ikomoka kuri pregnenolone. Ihuza na poroteyine 2 ifitanye isano na microtubule 2 (MAP2) mu buryo busa na pregnenolone kandi irimo gutezwa imbere kugira ngo ikoreshwe mu mavuriro ku bimenyetso nko kuvura ubwonko n'ubwonko bw'umugongo n'indwara yo kwiheba.
3% CE% B2-androsta-4,16-dien-3-ol / 4-Androstadienol: 4-Androstadienol , izwi kandi nka 4,16-androstadien-3β-ol , ni ferine irimo gutunganywa na VistaGen Therapeutics, Inc. muburyo bwo gutera amazuru ( PRN ) kugirango bivure bikabije indwara ziterwa no guhangayika. Harimo kandi gukorwaho iperereza na VistaGen Therapeutics yo kuvura indwara rusange yo guhangayika (GAD) hamwe n'ihungabana ry'ihungabana (PTSD) Ferine ni isomer ihagaze kuri ferogenone ya endogenous androstadienol. Kugeza muri 2020, iri mu cyiciro cya III cy'amavuriro kubibazo byo guhangayika.
3% CE% B2-androstanediol / 3β-Androstanediol: 3β-Androstanediol , izwi kandi nka 5α-androstane-3β, 17β-diol , kandi rimwe na rimwe ikagabanywa mu bitabo ikagera kuri 3β-diol , ni imisemburo ya endogenous steroid na metabolite ya androgene nka dehydroepiandrosterone (DHEA) na dihydrotestosterone (DHT).
3% CE% B2-androstenol / 3β-Androstenol: 3β-Androstenol , izwi kandi nka 5α-androst-16-en-3β-ol , ni feromone y'inyamabere isanzwe ibaho izwiho kuba mu bantu ningurube. Byatekerejweho kugira uruhare mumpumuro nziza. Ikorwa muri androstenone ikoresheje enzyme 3β-hydroxysteroid dehydrogenase. Bitandukanye na C3α epimer yayo 3α-androstenol, 3β-androstenol yerekana ko nta mbaraga za GABA A reseptor cyangwa ibikorwa bya anticonvulsant.
3% CE% B2-chlorocholest-5-ene / Cholesteryl chloride: Cholesteryl chloride , nanone yitwa 3-chlorocholest-5-ene cyangwa 3β-chlorocholest-5-ene , ni imiti kama, organogloride ikomoka kuri cholesterol. Nibintu byamazi ya kirisiti ikora amasaha ya cholesteric yamashanyarazi. Nibintu bisobanutse neza, cyangwa ibikoresho byoroshye bya kristaline bifite aho bishonga hafi 94-96 ° C.
3% CE% B2-cholest-5-en-3-ol nonaoate / Cholesteryl nonanoate: Cholesteryl nonanoate , nanone yitwa cholesteryl pelargonate , 3β-cholest-5-en-3-ol nonaoate cyangwa cholest-5-ene-3-β-yl nonanoate , ni ester ya cholesterol na aside aside. Nibintu byamazi ya kirisiti ikora cholesteric fluid kristal ifite imiterere ihindagurika. Ikora sisitemu ya spherulite.
3% CE% B2-cyclopentyl propionate_of_megestrol_acetate / Cymegesolate: Cymegesolate , izwi kandi nka cypionyl megestrol acetate cyangwa nka megestrol acetate 3β-cypionate , ni imiti ya progestine itigeze igurishwa. Yatunganijwe mu Bushinwa mu mpera za za 70 no mu ntangiriro kugeza hagati ya 1980 kugira ngo ikoreshwe mu kuboneza urubyaro. Imiti yakozwe ku kigero cya mg 50-100 ifatanije na "trace" ya 0,25-0.5 mg quinestrol nk'igihe kirekire, rimwe mu kwezi ikomatanya imiti yo kuboneza urubyaro. Ubu buryo bwakorewe ubushakashatsi ku bagore 1,213 mu gihe cy'imihango 9,651, hamwe no kuboneza urubyaro birenga 99.13% kandi "ni bike cyane." Ku kigero kinini, cyerekanaga igipimo cya anovulation kingana na 60% gusa, ahubwo gihuza ingaruka zacyo zo kuboneza urubyaro hakoreshejwe ingaruka zirwanya anti-implantation.
3% CE% B2-cyclopentylpropionate ya_megestrol_acetate / Cymegesolate: Cymegesolate , izwi kandi nka cypionyl megestrol acetate cyangwa nka megestrol acetate 3β-cypionate , ni imiti ya progestine itigeze igurishwa. Yatunganijwe mu Bushinwa mu mpera za za 70 no mu ntangiriro kugeza hagati ya 1980 kugira ngo ikoreshwe mu kuboneza urubyaro. Imiti yakozwe ku kigero cya mg 50-100 ifatanije na "trace" ya 0,25-0.5 mg quinestrol nk'igihe kirekire, rimwe mu kwezi ikomatanya imiti yo kuboneza urubyaro. Ubu buryo bwakorewe ubushakashatsi ku bagore 1,213 mu gihe cy'imihango 9,651, hamwe no kuboneza urubyaro birenga 99.13% kandi "ni bike cyane." Ku kigero kinini, cyerekanaga igipimo cya anovulation kingana na 60% gusa, ahubwo gihuza ingaruka zacyo zo kuboneza urubyaro hakoreshejwe ingaruka zirwanya anti-implantation.
3% CE% B2-cypionate ya_megestrol_acetate / Cymegesolate: Cymegesolate , izwi kandi nka cypionyl megestrol acetate cyangwa nka megestrol acetate 3β-cypionate , ni imiti ya progestine itigeze igurishwa. Yatunganijwe mu Bushinwa mu mpera za za 70 no mu ntangiriro kugeza hagati ya 1980 kugira ngo ikoreshwe mu kuboneza urubyaro. Imiti yakozwe ku kigero cya mg 50-100 ifatanije na "trace" ya 0,25-0.5 mg quinestrol nk'igihe kirekire, rimwe mu kwezi ikomatanya imiti yo kuboneza urubyaro. Ubu buryo bwakorewe ubushakashatsi ku bagore 1,213 mu gihe cy'imihango 9,651, hamwe no kuboneza urubyaro birenga 99.13% kandi "ni bike cyane." Ku kigero kinini, cyerekanaga igipimo cya anovulation kingana na 60% gusa, ahubwo gihuza ingaruka zacyo zo kuboneza urubyaro hakoreshejwe ingaruka zirwanya anti-implantation.
3% CE% B2-dihydroprogesterone / 3β-Dihydroprogesterone: 3β-Dihydroprogesterone ( 3β-DHP ), izwi kandi nka 3β-hydroxyprogesterone , cyangwa inda-4-en-3β-ol-20-imwe , ni steroid endogenous. Ni biosynthesize na 3β-hydroxysteroid dehydrogenase ikomoka kuri progesterone. Bitandukanye na 3α-dihydroprogesterone (3α-DHP), 3β-DHP ntabwo ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor , ibyo bikaba bihuye nuko izindi 3β-hydroxylated progesterone metabolite nka isopregnanolone na epipregnanolone nayo idakora nka potentiator ziyi reseptor ahubwo ikabuza kimwe no guhindura ingaruka za potentiator nka allopregnanolone. 3β-DHP byavuzwe ko ifite imbaraga zingana na progesterone muri bioassay yibikorwa bya progestogenic, mugihe 3α-DHP itigeze isuzumwa.
3% CE% B2-etiocholanediol / 3β-Etiocholanediol: 3β-Etiocholanediol , cyangwa epietiocholanediol , izwi kandi nka 3β, 5β-androstanediol cyangwa nka etiocholane-3β, 17β-diol , ni etiocholane (5β-androstane) steroid na metabolite ya endogenous ya testosterone. Yakozwe kuva 5β-dihydrotestosterone kandi ihinduka epietiocholanolone.
3% CE% B2-hydoxy-5% CE% B1-gutwita-20-umwe / Isopregnanolone: Isopregnanolone , izwi kandi ku izina rya isoallopregnanolone na epiallopregnanolone , ndetse na sepranolone ( INN ), kandi nka 3β-hydroxy-5α-gutwita-20-umwe cyangwa 3β, 5α-tetrahydroprogesterone ( 3β, 5α-THP ), ni neurosteroid na endogenous neurosteroid na a karemano 3β-epimer ya allopregnanolone. Byaravuzwe ko ikora nka subunit-selitifike mbi ya allosteric modulator ya GABA A yakira , kandi ikarwanya inyamaswa n'abantu bamwe ariko siko bose ba GABA A reseptor-medrated medrated of allopregnanolone, nka anesthesia, sedation, ndetse no kugabanya saccadic kugenda kw'amaso, ariko kutiga ubumuga. Isopregnanolone nta ngaruka za hormone kandi bigaragara ko nta ngaruka igira kuri GABA A reseptor yonyine; ihitamo kurwanya allopregnanolone kandi ntabwo ihindura ingaruka zubundi bwoko bwa GABA A reseptor nziza ya allosteric modulator nka benzodiazepine cyangwa barbiturates.
3% CE% B2-hydroxypregn-4-en-20-umwe / 3β-Dihydroprogesterone: 3β-Dihydroprogesterone ( 3β-DHP ), izwi kandi nka 3β-hydroxyprogesterone , cyangwa inda-4-en-3β-ol-20-imwe , ni steroid endogenous. Ni biosynthesize na 3β-hydroxysteroid dehydrogenase ikomoka kuri progesterone. Bitandukanye na 3α-dihydroprogesterone (3α-DHP), 3β-DHP ntabwo ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor , ibyo bikaba bihuye nuko izindi 3β-hydroxylated progesterone metabolite nka isopregnanolone na epipregnanolone nayo idakora nka potentiator ziyi reseptor ahubwo ikabuza kimwe no guhindura ingaruka za potentiator nka allopregnanolone. 3β-DHP byavuzwe ko ifite imbaraga zingana na progesterone muri bioassay yibikorwa bya progestogenic, mugihe 3α-DHP itigeze isuzumwa.
3% CE% B2-hydroxyprogesterone / 3β-Dihydroprogesterone: 3β-Dihydroprogesterone ( 3β-DHP ), izwi kandi nka 3β-hydroxyprogesterone , cyangwa inda-4-en-3β-ol-20-imwe , ni steroid endogenous. Ni biosynthesize na 3β-hydroxysteroid dehydrogenase ikomoka kuri progesterone. Bitandukanye na 3α-dihydroprogesterone (3α-DHP), 3β-DHP ntabwo ikora nka moderi nziza ya allosteric modulator ya GABA A reseptor , ibyo bikaba bihuye nuko izindi 3β-hydroxylated progesterone metabolite nka isopregnanolone na epipregnanolone nayo idakora nka potentiator ziyi reseptor ahubwo ikabuza kimwe no guhindura ingaruka za potentiator nka allopregnanolone. 3β-DHP byavuzwe ko ifite imbaraga zingana na progesterone muri bioassay yibikorwa bya progestogenic, mugihe 3α-DHP itigeze isuzumwa.
3% CE% B2-hydroxysteroid dehydrogenase / 3β-Hydroxysteroid dehydrogenase: 3β-Hydroxysteroid dehydrogenase / Δ 5-4 isomerase ( 3β-HSD ) ni umusemburo utera biosynthesis ya steroid progesterone kuva kuri pregnenolone, 17α-hydroxyprogesterone kuva 17α-hydroxypregnenolone, na androstenedione kuva dehydroepiandrosterone (DHEA). Ni enzyme yonyine mumuhanda wa adrenal ya synthesis ya corticosteroid itari mubanyamuryango ba cytochrome P450. Iraboneka kandi mubindi bice bitanga steroid, harimo intanga ngore, testis na plasita. Mu bantu, hariho isozymes ebyiri 3β-HSD zashyizweho na gen ya HSD3B1 na HSD3B2.
3% CE% B2-hydroxysteroid dehydrogenase_2 / HSD3B2: HSD3B2 ni gene yumuntu igizwe na 3beta-hydroxysteroid dehydrogenase / delta (5) -delta (4) isomerase ubwoko bwa II cyangwa hydroxy-delta-5-steroid dehydrogenase, 3 beta- na steroid delta-isomerase 2 . Igaragarira cyane cyane mubice bya steroidogenic kandi ni ngombwa mugukora imisemburo ya steroid. Ibidasanzwe bigaragara ni insimburangingo, aho HSD3B1 ari ingenzi kubyara progesterone niyi tissue.
3% CE% B2-hydroxysteroid dehydrogenase_2_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-hydroxysteroid dehydrogenase_II_ibura / hyperplasia ivuka adrenal ivuka kubera 3β-hydroxysteroid dehydrogenase ibura: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-hydroxysteroid dehydrogenase_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-hydroxysteroid dehydrogenase_ubwoko_2_ubuke / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-hydroxysteroid dehydrogenase_ubwoko_II_ibura / hyperplasia ivuka adrenal ivuka kubera kubura 3β-hydroxysteroid dehydrogenase: Indwara ya hyperplasia ivuka bitewe na 3β-hydroxysteroid dehydrogenase ibura ni uburyo budasanzwe bwo kuvuka kwa adrenal hyperplasia (CAH) biva mu ihinduka rya gene kuri imwe mu misemburo y'ingenzi muri synthesis ya cortisol na glande ya adrenal, 3β-hydroxysteroid dehydrogenase (3β-HSD ) ubwoko bwa II (HSD3B2). Kubera iyo mpamvu, urwego rwo hejuru rwa 17α-hydroxypregnenolone rugaragara mu maraso hamwe n'imisemburo ya adrenocorticotropic hormone (ACTH), itera synthesis ya adrenal corticosteroid.
3% CE% B2-hydroxytibolone / 3β-Hydroxytibolone: 3β-Hydroxytibolone ni estrogene ya steroidal steroidal itigeze igurishwa. Hamwe na 3α-hydroxytibolone na δ 4 -tibolone , ni metabolite ikomeye ya tibolone, na 3α-hydroxytibolone na 3β-hydroxytibolone batekereza ko aribo bashinzwe ibikorwa bya estrogeneque ya tibolone.
3% CE% B2-mikorerexypregnenolone / 3β-Methoxypregnenolone: 3β-Methoxypregnenolone , cyangwa inda 3β-methyl ether , izwi kandi nka 3β-mikorerexypregn-5-en-20-imwe , ni sintetike ya neuroactive steroid kandi ikomoka kuri pregnenolone. Ihuza na poroteyine 2 ifitanye isano na microtubule 2 (MAP2) mu buryo busa na pregnenolone kandi irimo gutezwa imbere kugira ngo ikoreshwe mu mavuriro ku bimenyetso nko kuvura ubwonko n'ubwonko bw'umugongo n'indwara yo kwiheba.
3% CE% B2HSD2 / HSD3B2: HSD3B2 ni gene yumuntu igizwe na 3beta-hydroxysteroid dehydrogenase / delta (5) -delta (4) isomerase ubwoko bwa II cyangwa hydroxy-delta-5-steroid dehydrogenase, 3 beta- na steroid delta-isomerase 2 . Igaragarira cyane cyane mubice bya steroidogenic kandi ni ngombwa mugukora imisemburo ya steroid. Ibidasanzwe bigaragara ni insimburangingo, aho HSD3B1 ari ingenzi kubyara progesterone niyi tissue.
3% CE% B2HSD 2 / HSD3B2: HSD3B2 ni gene yumuntu igizwe na 3beta-hydroxysteroid dehydrogenase / delta (5) -delta (4) isomerase ubwoko bwa II cyangwa hydroxy-delta-5-steroid dehydrogenase, 3 beta- na steroid delta-isomerase 2 . Igaragarira cyane cyane mubice bya steroidogenic kandi ni ngombwa mugukora imisemburo ya steroid. Ibidasanzwe bigaragara ni insimburangingo, aho HSD3B1 ari ingenzi kubyara progesterone niyi tissue.
3% CE% B2HSD II / 3β-Hydroxysteroid dehydrogenase: 3β-Hydroxysteroid dehydrogenase / Δ 5-4 isomerase ( 3β-HSD ) ni umusemburo utera biosynthesis ya steroid progesterone kuva kuri pregnenolone, 17α-hydroxyprogesterone kuva 17α-hydroxypregnenolone, na androstenedione kuva dehydroepiandrosterone (DHEA). Ni enzyme yonyine mumuhanda wa adrenal ya synthesis ya corticosteroid itari mubanyamuryango ba cytochrome P450. Iraboneka kandi mubindi bice bitanga steroid, harimo intanga ngore, testis na plasita. Mu bantu, hariho isozymes ebyiri 3β-HSD zashyizweho na gen ya HSD3B1 na HSD3B2.
3% CF% 89-uburyo / 3ω-buryo: 3ω-uburyo cyangwa 3ω-tekinike, nuburyo bwo gupima uburyo bwo kumenya ubushyuhe bwumuriro bwibintu byinshi kandi byoroshye. Inzira ikubiyemo icyuma gishyushya cyashyizwe kuri sample ishyuha buri gihe. Ubushyuhe bwo guhindagurika rero bwakozwe noneho bupimwa. Ubushuhe bwumuriro hamwe nubushuhe bwumuriro wintangarugero birashobora kugenwa uhereye kubihe biterwa. Iyi gahunda yatangajwe bwa mbere na David Cahill na Robert Pohl mu nomero yo muri Mata 1987 y'isuzuma ry'umubiri mu mpapuro bise "Ubushyuhe bw'ubushyuhe bwa Amorphous Solide hejuru ya Plateau".
3% E2% 80% 9322 Gloucester_Crescent / Ukwezi kwa Gloucester, Kamden: Gloucester Crescent ni ukwezi kwa 1840 gutura kwa Victorian mu mujyi wa Camden mu mujyi wa Londres aho guhera mu ntangiriro ya za 1960 wamamaye muri bohemia nk '"umuhanda ugenda neza cyane i Londres" na "Umuhanda w'ubwenge w'Ubwongereza" ubwo wabaye inzu y'abanditsi benshi b'abongereza, abahanzi n'abanyabwenge barimo Jonathan Miller, Alan Bennett na Alice Thomas Ellis.
3% E2% 80% 9331 Northgate_Street, _Chester / 3-31 Umuhanda wa Northgate, Chester: 3-31 Umuhanda wa Northgate ni amaterasi y amaduka, biro ninzu ya rubanda kuruhande rwiburengerazuba bwumuhanda wa Northgate, Chester, Cheshire, mubwongereza. Inyubako zose zifite igorofa yinyuma-yubatswe hamwe n'inzira zipfundikijwe, zikozwe mu biti mu igorofa ryabo ryo hejuru, kandi zashyizwe ku rutonde inyubako, zashyizwe mu cyiciro cya II * cyangwa II. Igice cy'amaterasi kigizwe nimibare 5-31 kizwi ku izina rya Shoemakers 'Row, cyangwa Sadler's Row.
3% E2% 80% 933% E2% 80% 935 kwirwanaho / 3–3-5 kwirwanaho: Mu mupira wamaguru wabanyamerika, kwirwanaho 3–3-5 ni uguhuza kwirwanaho bigizwe nabakinnyi batatu bamanuka, batatu bakina inyuma, hamwe ninyuma yinyuma. Ubwunganizi bwa 3–3-5 bushobora nanone kwitwa stack 3-3 hamwe na Spread Defence . Nuburyo bumwe bwo kwirwanaho bwa nikel, ijambo rusange ryo gushiraho hamwe ninyuma eshanu zo kwirwanaho. Umuhuzabikorwa wokwirinda umupira wamaguru muri kaminuza Joe Lee Dunn arashimirwa cyane kuba ari we mushya udushya muri gahunda ya 3-3-5.
3% E2% 80% 934 / 3–4 kwirwanaho: Mu mupira wamaguru wabanyamerika, kwirwanaho 3-4 ni uguhuza kwirwanaho bigizwe nabantu batatu bamanuka hasi hamwe nabakinnyi bane. Nicyo bita "base defence" kuko nuburyo busanzwe bwo kwirwanaho bukoreshwa kuri "hasi hasi". Ariko, kwirwanaho bizahita bihinduka mubindi bihuza kwirwanaho uko ibintu bihinduka. Ubundi, kwirwanaho bimwe bikoresha kwirwanaho 4–3.
3% E2% 80% 934 kwirwanaho / 3-4 kwirwanaho: Mu mupira wamaguru wabanyamerika, kwirwanaho 3-4 ni uguhuza kwirwanaho bigizwe nabantu batatu bamanuka hasi hamwe nabakinnyi bane. Nicyo bita "base defence" kuko nuburyo busanzwe bwo kwirwanaho bukoreshwa kuri "hasi hasi". Ariko, kwirwanaho bizahita bihinduka mubindi bihuza kwirwanaho uko ibintu bihinduka. Ubundi, kwirwanaho bimwe bikoresha kwirwanaho 4–3.
3% E2% 80% 934% E2% 80% 933 gushiraho / Gushinga (umupira wamaguru wishyirahamwe): Mu ishyirahamwe ry'umupira w'amaguru, ishingwa risobanura uburyo abakinnyi mu ikipe muri rusange bahagaze mu kibuga. Ishyirahamwe ry'umupira w'amaguru ni umukino utemba kandi wihuta, kandi umwanya wumukinnyi mumiterere ntusobanura uruhare rwabo nkurugero, nkumukinnyi wa ruhago, ntanubwo hari ibice bikinirwa aho abakinnyi bagomba gutonda umurongo muburyo bwo gushinga. Nubwo bimeze bityo ariko, umwanya wumukinnyi mumiterere asobanura niba umukinnyi afite uruhare runini rwo kwirwanaho cyangwa gutera, kandi niba bakunda gukina kuruhande rumwe rwikibuga cyangwa hagati.
3% E2% 80% 936 Guilford_ Umwanya / 3-6 Guilford Ahantu: Ikibanza cya Guilford ni Icyiciro cya II cyashyizwe ahagaragara amaterasi y'indinganire ya Jeworujiya y'amazu ane ahitwa Guilford Place, London WC1, yubatswe ahagana mu 1791 kugeza 1793 na J. Tomes na W. Harrison.
3% E2% 80% 939 Brompton_Square / Ikibanza cya Brompton: Brompton Square ni ubusitani mu karere ka Londres ka Brompton, muri Royal Borough ya Kensington na Chelsea.
3% E2% 80% 99 / Icyerekezo (biologiya ya molekuline): Icyerekezo , muri biyolojiya ya biologiya na biohimiya, nicyerekezo cya chimique iherezo-iherezo ryumurongo umwe wa aside nucleique. Mu murongo umwe wa ADN cyangwa RNA, amasezerano yimiti yo kwita atome ya karubone muri nucleotide pentose-isukari-impeta bivuze ko hazaba 5 ′ -end, ikunze kuba irimo itsinda rya fosifate ifatanye na 5 ′ karubone ya ribose impeta, na 3 ′ -end, mubisanzwe idahinduwe kuva ribose -OH. Muri ADN ya kabiri ya helix, imirongo ikora mu cyerekezo gitandukanye kugirango yemererwe guhuza hagati yabo, ari ngombwa mu kwigana cyangwa kwandukura amakuru yashizweho.
3% E2% 80% 99UTR / Intara eshatu zingenzi zidasobanuwe: Muri genetiki ya molekulike, uturere dutatu twibanze tutarasobanuwe ( 3′-UTR ) nigice cyintumwa RNA (mRNA) ihita ikurikira codon yo guhagarika ibisobanuro. 3′-UTR ikunze kubamo uturere tugenzura nyuma yinyandiko-mvugo bigira ingaruka kumvugo ya gene.
3% E2% 80% 99 UTR / Intara eshatu zingenzi zidasobanuwe: Muri genetiki ya molekulike, uturere dutatu twibanze tutarasobanuwe ( 3′-UTR ) nigice cyintumwa RNA (mRNA) ihita ikurikira codon yo guhagarika ibisobanuro. 3′-UTR ikunze kubamo uturere tugenzura nyuma yinyandiko-mvugo bigira ingaruka kumvugo ya gene.