4%E2%80%934%E2%80%932 formation/Formation (association football), 4%E2%80%934%E2%80%935 calendar/4–4–5 calendar

4% E2% 80% 934% E2% 80% 932 gushiraho / Gushinga (umupira wamaguru wishyirahamwe): Mu ishyirahamwe ry'umupira w'amaguru, ishingwa risobanura uburyo abakinnyi mu ikipe muri rusange bahagaze mu kibuga. Ishyirahamwe ryumupira wamaguru ni umukino utemba kandi wihuta, kandi umwanya wumukinnyi mumiterere ntusobanura uruhare rwabo nkurugero, nkumukinnyi wa ruhago, ntanubwo hari ibice bikinirwa aho abakinnyi bagomba gutonda umurongo muburyo bwo gushinga. Nubwo bimeze bityo ariko, umwanya wumukinnyi muburyo busanzwe usobanura niba umukinnyi afite uruhare runini rwo kwirwanaho cyangwa gutera, kandi niba bakunda gukina kuruhande rumwe rwikibuga cyangwa hagati.
4% E2% 80% 934% E2% 80% 935 kalendari / 4-4-5 kalendari: Kalendari ya 4–4-5 nuburyo bwo gucunga igihe cyibaruramari , kandi ni imiterere rusange yingengabihe yinganda zimwe nko gucuruza no gukora.
4% E2% 80% 935% E2% 80% 931 / Gushinga (umupira wamaguru wishyirahamwe): Mu ishyirahamwe ry'umupira w'amaguru, ishingwa risobanura uburyo abakinnyi mu ikipe muri rusange bahagaze mu kibuga. Ishyirahamwe ryumupira wamaguru ni umukino utemba kandi wihuta, kandi umwanya wumukinnyi mumiterere ntusobanura uruhare rwabo nkurugero, nkumukinnyi wa ruhago, ntanubwo hari ibice bikinirwa aho abakinnyi bagomba gutonda umurongo muburyo bwo gushinga. Nubwo bimeze bityo ariko, umwanya wumukinnyi muburyo busanzwe usobanura niba umukinnyi afite uruhare runini rwo kwirwanaho cyangwa gutera, kandi niba bakunda gukina kuruhande rumwe rwikibuga cyangwa hagati.
4% E2% 80% 936% E2% 80% 932 / 4-6-2: Munsi ya Whyte yamenyesheje ibyiciro bya moteri, 4-6-2 byerekana gahunda yibiziga byiziga bine biganisha kumirongo ibiri, ibiziga bitandatu bifite imbaraga kandi bifatanyirijwe hamwe kumirongo itatu ninziga ebyiri zikurikirana kumurongo umwe. Lokomoteri 4-6-2 yamenyekanye kwisi yose izwi nkubwoko bwa pasifika .
4% E2% 80% 938a Rutland_Irembo / 2–8a Irembo rya Rutland: Irembo rya Rutland ni inzu nini y'amaterasi y'indinganire ku Irembo rya Rutland mu karere ka Knightsbridge i Londres, ireba Parike ya Hyde. Yahoze ari amazu ane yubatswe nk'Irembo rya Rutland 2 na 4-8a Irembo rya Rutland, ariko amazu yahinduwe umutungo umwe hagati ya za 1980.
4% E2% 80% 9933% E2% 80% 9D / 4′33 ″: 4′33 ″ ni ibice bitatu bigize ibihangano byakozwe numunyamerika wigeragezwa John Cage (1912–1992). Yahimbwe mu 1952, kubikoresho byose cyangwa guhuza ibikoresho, kandi amanota ategeka abahanzi kudacuranga ibikoresho byabo mugihe cyose cyigihe cyose mugice cyose. Igice kigizwe nijwi ryibidukikije abumva bumva mugihe bikozwe, nubwo bikunze gufatwa nk "iminota ine amasegonda mirongo itatu n'atatu yo guceceka". Umutwe wigice bivuga uburebure bwuzuye muminota namasegonda yimikorere runaka, 4′33 ″ kuba uburebure bwuzuye bwibikorwa rusange.
4% E2% 80% 9933% E2% 80% B3 / 4′33 ″: 4′33 ″ ni ibice bitatu bigize ibihangano byakozwe numunyamerika wigeragezwa John Cage (1912–1992). Yahimbwe mu 1952, kubikoresho byose cyangwa guhuza ibikoresho, kandi amanota ategeka abahanzi kudacuranga ibikoresho byabo mugihe cyose cyigihe cyose mugice cyose. Igice kigizwe nijwi ryibidukikije abumva bumva mugihe bikozwe, nubwo bikunze gufatwa nk "iminota ine amasegonda mirongo itatu n'atatu yo guceceka". Umutwe wigice bivuga uburebure bwuzuye muminota namasegonda yimikorere runaka, 4′33 ″ kuba uburebure bwuzuye bwibikorwa rusange.
4% E2% 80% B2,5,7-trihydroxy-6-methylflavanone / Poriol: Poriol ni C-methylated flavanone, ubwoko bwa flavonoid. Iboneka muri Pseudotsuga menziesii mugukemura kwandura na Poria weirii .
4% E2% 80% B2,7-dihydroxyflavone / 4 ', 7-Dihydroxyflavone: 4 ', 7-Dihydroxyflavone ni flavone. Iboneka muri Medicago truncatula bijyanye numuzi nodulation symbiont Sinorhizobium meliloti cyangwa mu mbuto za Sophora viciifolia .
4% E2% 80% B2-Ethynyl-2-fluoro-2% E2% 80% B2-deoxyadenosine / Islatravir: Islatravir numuti wiperereza wo kuvura ubwandu bwa virusi itera sida. Byashyizwe mubikorwa nka nucleoside reverse transcriptase translocation inhibitor (NRTTI). Merck irimo guteza imbere imiti igabanya ubukana bwa islatravir.
4% E2% 80% B2-Fluorococaine / 4′-Fluorococaine: 4′-Fluorococaine ni imiti ikomoka kuri tropane ikaba ari analogue ya kokayine. Bitandukanye n'ibintu bifitanye isano nka 4′-fluorophenyltropane ikomoka kuri CFT hamwe na 2′-hydroxy analogue salicylmethylecgonine, 4′-fluorococaine ifite imbaraga zingana na kokayine gusa nk'ibuza gufata dopamine, ariko ku rundi ruhande ni serotonine ikomeye. inhibitor kuruta kokayine, bivamo imiterere ya farumasi ihindagurika cyane mubushakashatsi bwinyamaswa.
4% E2% 80% B2-Fluorotroparil / WIN-35428: (-) - 2-β-Carbomethoxy-3-β- (4-fluorophenyl) tropane ni imiti itera imbaraga ikoreshwa mubushakashatsi bwa siyansi. CFT ni feniltropane ishingiye kuri dopamine reuptake inhibitor kandi ikomoka muburyo bwa kokayine. Ifite imbaraga za 3-10x kurusha kokayine kandi imara hafi inshuro 7 zishingiye ku bushakashatsi bw'inyamaswa. Mugihe umunyu wa naphthalenedisulfonate aribwo buryo bukoreshwa cyane mubushakashatsi bwa siyansi bitewe nubushake buke bwamazi, amazi yubusa hamwe nu munyu wa hydrochloride uzwi cyane kandi ushobora no kubyara. Tartrate nubundi buryo bwumunyu bivugwa.
4% E2% 80% B2-Ethynyl-2-fluoro-2% E2% 80% B2-deoxyadenosine / Islatravir: Islatravir numuti wiperereza wo kuvura ubwandu bwa virusi itera sida. Byashyizwe mubikorwa nka nucleoside reverse transcriptase translocation inhibitor (NRTTI). Merck irimo guteza imbere imiti igabanya ubukana bwa islatravir.
4% E2% 80% B2-hydroxyacetophenone / Piceol: Piceol ni ifumbire mvaruganda iboneka mu nshinge no mu mizi ya mycorrhizal ya Noruveje. Picein ni glucoside ya piceol.
4% E2% 80% B233% 27 / 4′33 ″: 4′33 ″ ni ibice bitatu bigize ibihangano byakozwe numunyamerika wigeragezwa John Cage (1912–1992). Yahimbwe mu 1952, kubikoresho byose cyangwa guhuza ibikoresho, kandi amanota ategeka abahanzi kudacuranga ibikoresho byabo mugihe cyose cyigihe cyose mugice cyose. Igice kigizwe nijwi ryibidukikije abumva bumva mugihe bikozwe, nubwo bikunze gufatwa nk "iminota ine amasegonda mirongo itatu n'atatu yo guceceka". Umutwe wigice bivuga uburebure bwuzuye muminota namasegonda yimikorere runaka, 4′33 ″ kuba uburebure bwuzuye bwibikorwa rusange.
4% E2% 80% B233% E2% 80% B3 / 4′33 ″: 4′33 ″ ni ibice bitatu bigize ibihangano byakozwe numunyamerika wigeragezwa John Cage (1912–1992). Yahimbwe mu 1952, kubikoresho byose cyangwa guhuza ibikoresho, kandi amanota ategeka abahanzi kudacuranga ibikoresho byabo mugihe cyose cyigihe cyose mugice cyose. Igice kigizwe nijwi ryibidukikije abumva bumva mugihe bikozwe, nubwo bikunze gufatwa nk "iminota ine amasegonda mirongo itatu n'atatu yo guceceka". Umutwe wigice bivuga uburebure bwuzuye muminota namasegonda yimikorere runaka, 4′33 ″ kuba uburebure bwuzuye bwibikorwa rusange.
4% E2% 80% B2 33% E2% 80% B3 / 4′33 ″: 4′33 ″ ni ibice bitatu bigize ibihangano byakozwe numunyamerika wigeragezwa John Cage (1912–1992). Yahimbwe mu 1952, kubikoresho byose cyangwa guhuza ibikoresho, kandi amanota ategeka abahanzi kudacuranga ibikoresho byabo mugihe cyose cyigihe cyose mugice cyose. Igice kigizwe nijwi ryibidukikije abumva bumva mugihe bikozwe, nubwo bikunze gufatwa nk "iminota ine amasegonda mirongo itatu n'atatu yo guceceka". Umutwe wigice bivuga uburebure bwuzuye muminota namasegonda yimikorere runaka, 4′33 ″ kuba uburebure bwuzuye bwibikorwa rusange.
4% E2% 81% 845 KIX / Kix (band): Kix nitsinda ryabanyamerika glam nicyuma gikomeye cyitsinda ryamamaye mugihe cya 1980. Bayobowe n'umukinnyi w'imbere Steve Whiteman na Donnie Purnell, bassiste, itsinda ry'abacuranzi ba kera ryazengurutswe n'ingoma Jimmy "Chocolate" Chalfant hamwe n'abacuranga gitari Ronnie "10/10" Younkins na Brian "Kwangiza" Forsythe. Kix yakoresheje AC / DC, Aerosmith, Mata Wine, Led Zeppelin n'abandi, mbere yo gusinyana na Atlantic Records mu 1981. Kuva aho bigeze mu mpera za za 1980, abagize itsinda bakomeje kwandika rimwe na rimwe no kuzenguruka, harimo n'umunsi mukuru wa Rocklahoma mu 2008 muri Oklahoma kandi ni abantu bahari mu iserukiramuco rya M3 rya buri mwaka muri leta ya Maryland.
4% E2% 81% 845 Kix / Kix (band): Kix nitsinda ryabanyamerika glam nicyuma gikomeye cyitsinda ryamamaye mugihe cya 1980. Bayobowe n'umukinnyi w'imbere Steve Whiteman na Donnie Purnell, bassiste, itsinda ry'abacuranzi ba kera ryazengurutswe n'ingoma Jimmy "Chocolate" Chalfant hamwe n'abacuranga gitari Ronnie "10/10" Younkins na Brian "Kwangiza" Forsythe. Kix yakoresheje AC / DC, Aerosmith, Mata Wine, Led Zeppelin n'abandi, mbere yo gusinyana na Atlantic Records mu 1981. Kuva aho bigeze mu mpera za za 1980, abagize itsinda bakomeje kwandika rimwe na rimwe no kuzenguruka, harimo n'umunsi mukuru wa Rocklahoma mu 2008 muri Oklahoma kandi ni abantu bahari mu iserukiramuco rya M3 rya buri mwaka muri leta ya Maryland.
4% E2% 82% 81 ipfundo / Igishushanyo-umunani ipfundo (imibare): Mu ipfundo, ipfundo -umunani ni ipfundo ryihariye rifite umubare wambukiranya bane. Ibi bituma ipfundo hamwe numwanya wa gatatu-muto muto ushobora kwambuka, nyuma yipfundikizo hamwe na trfoil. Ifoto-umunani ipfundo ni ipfundo ryibanze.
4% E2% 88% 92 / Coxless enye: Coxless enye ni ubwato bwo koga bukoreshwa muri siporo yo kwiruka. Yagenewe abantu bane bazamura ubwato bafite ubwato bunini.
4% EF% B8% 8F% E2% 83% A3 / 4: 4 ( bine ) numubare, imibare numubare. Numubare karemano ukurikira 3 nuwabanjirije 5. Numubare muto ugereranije, kandi ufatwa nkamahirwe mumico myinshi yo muri Aziya y'Uburasirazuba.
5/5: 5 ( gatanu ) numubare, imibare numubare. Numubare usanzwe ukurikira 4 na 6 ibanziriza 6, kandi numubare wambere. Yagize akamaro mu mateka igice kuko abantu basanzwe bafite imibare itanu kuri buri kuboko.
5% 22 FFAR / 5-Inch Imbere yo Kurasa Indege Roketi: Indege ya Rocket cyangwa FFAR ya santimetero 5 ni roketi y'Abanyamerika yakozwe mu gihe cy'Intambara ya Kabiri y'Isi Yose kugira ngo ibitero by'indege byibasire ku butaka no ku bwato.
5% 22 floppy / Disiki ya disiki: Disiki ya disiki cyangwa disiki ni ubwoko bwububiko bwa disiki bugizwe na disiki yoroheje kandi yoroheje yububiko bwa magnetiki yububiko bwa kare cyangwa hafi ya kare ya plastike yegeranye hamwe nigitambara gikuramo ivumbi muri disiki izunguruka. Disiki ya Floppy irasomwa kandi ikandikwa na disiki ya disiki ( FDD ).
5% 22x7% 22 / Ingano yerekana amafoto: Ingano isanzwe yo gufotora ikoreshwa mugucapura amafoto. Gukata impapuro zigenewe gucapa amafoto bikunze kugurishwa muribi binini.
5% 25 Igihugu / Igihugu gitanu-ijana: Igihugu Cy'ibice bitanu ku ijana , rimwe na rimwe byitwa Igihugu cy'Imana n'isi ( NGE / NOGE ) cyangwa bitanu ku ijana , ni umuryango w'umuco uyobowe n'ubuyisilamu washinzwe mu 1964 mu gice cya Harlem cy'akarere ka Manhattan, Umujyi wa New York, na Allah Data, wahoze azwi nka Clarence 13X na, mbere yibyo, Clarence Edward Smith.
5% 25 NoI / Igihugu gitanu-ijana: Igihugu Cy'ibice bitanu ku ijana , rimwe na rimwe byitwa Igihugu cy'Imana n'isi ( NGE / NOGE ) cyangwa bitanu ku ijana , ni umuryango w'umuco uyobowe n'ubuyisilamu washinzwe mu 1964 mu gice cya Harlem cy'akarere ka Manhattan, Umujyi wa New York, na Allah Data, wahoze azwi nka Clarence 13X na, mbere yibyo, Clarence Edward Smith.
5% 25 Nyirubwite / Ifishi 10-K: Ifishi 10-K ni raporo yumwaka isabwa na komisiyo ishinzwe kugurizanya no kugurizanya muri Amerika (SEC), itanga incamake yuzuye yimikorere yikigo. Nubwo bisa nkaho, raporo yumwaka ku ifishi ya 10-K itandukanye na "raporo yumwaka ku banyamigabane," isosiyete igomba kohereza abanyamigabane bayo iyo ikora inama ngarukamwaka yo gutora abayobozi. 10-K ikubiyemo amakuru nkamateka yisosiyete, imiterere yinzego, indishyi nyobozi, uburinganire, amashami, hamwe na raporo yimari yagenzuwe, hamwe nandi makuru.
5% 25 Tint / Astroworld (alubumu): Astroworld ni alubumu ya gatatu ya studio yakozwe numuraperi wumunyamerika akaba na producer Travis Scott. Yasohotse ku ya 3 Kanama 2018, ibinyujije muri Cactus Jack Records na Grand Hustle Records, ikwirakwizwa na Epic Records. Iyi alubumu ikurikira alubumu ye ya kabiri ya studio Inyoni mu mutego uririmba McKnight (2016), na alubumu yakoranye na Huncho Jack, Jack Huncho (2017) na Quavo.
5% 25 Tint_ (indirimbo) / Inyenyeri (alubumu): Astroworld ni alubumu ya gatatu ya studio yakozwe numuraperi wumunyamerika akaba na producer Travis Scott. Yasohotse ku ya 3 Kanama 2018, ibinyujije muri Cactus Jack Records na Grand Hustle Records, ikwirakwizwa na Epic Records. Iyi alubumu ikurikira alubumu ye ya kabiri ya studio Inyoni mu mutego uririmba McKnight (2016), na alubumu yakoranye na Huncho Jack, Jack Huncho (2017) na Quavo.
5% 25 Ibitekerezo / Senga 4 Urukundo: Senga 4 Urukundo ni alubumu ya kabiri ya studio yumuraperi wumunyamerika Rod Wave. Yasohotse ku ya 3 Mata 2020, binyuze muri Alamo Records. Iyi alubumu ikubiyemo ubufatanye bumwe burimo umuraperi wumunyamerika ATR Son Son kumurongo "Rags2Riches". Igitabo cya deluxe cyasohotse ku ya 7 Kanama 2020, kirimo Yo Gotti na Lil Baby, icya nyuma kuri remix ya "Rags2Riches". Indirimbo 12 muri alubumu zashyizwe ku rutonde rwa Billboard Hot 100 , hamwe na "Rags2Riches" ibaye indirimbo yamamaye cyane ya Rod Wave, igera ku mwanya wa 12. Amashusho y'indirimbo yashyizwe ahagaragara ku ndirimbo zose za alubumu.
5% 25 alubumu / Album ya 5%: Album ya 5% niyo alubumu yonyine yakozwe numuraperi wumunyamerika Lord Jamar, uzwi cyane nkumunyamuryango witsinda Brand Nubian.
5% 25 dextrose / Umuti w'isukari winjiza: Umuti w'isukari winjira , uzwi kandi nka dextrose , ni uruvange rwa dextrose (glucose) n'amazi. Ikoreshwa mukuvura isukari nke mumaraso cyangwa gutakaza amazi nta gutakaza electrolyte. Gutakaza amazi nta gutakaza electrolyte bishobora kugaragara mu muriro, hyperthyroidism, calcium yamaraso menshi, cyangwa insipidus ya diabete. Ikoreshwa kandi mukuvura potasiyumu yamaraso menshi, ketoacidose ya diabete, no mubice byimirire yababyeyi. Itangwa no gutera inshinge.
5% 263 GCR / Itsinda ryanditseho amajwi: Muri siyanse ya mudasobwa, itsinda ryanditseho amajwi cyangwa itsinda ryandika amajwi ( GCR ) bivuga uburyo butandukanye ariko bujyanye na kodegisi ya media. Iya mbere, yakoreshejwe muri 6250 bpi magnetiki kaseti kuva 1973, ni kode ikosora ikomatanya hamwe nuburebure burebure (RLL) gahunda yo gushushanya, iri mumatsinda ya code ya modulation. Izindi ni disiki nkuru yibanze ya disiki kimwe na disiki ya disiki ya disiki ikoreshwa muri microcomputer zimwe kugeza mu mpera za 1980. GCR nuburyo bwahinduwe bwa kode ya NRZI, ariko byanze bikunze hamwe ninzibacyuho yo hejuru.
5% 263 kodegisi / Itsinda ryanditseho amajwi: Muri siyanse ya mudasobwa, itsinda ryanditseho amajwi cyangwa itsinda ryandika amajwi ( GCR ) bivuga uburyo butandukanye ariko bujyanye na kodegisi ya media. Iya mbere, yakoreshejwe muri 6250 bpi magnetiki kaseti kuva 1973, ni kode ikosora ikomatanya hamwe nuburebure burebure (RLL) gahunda yo gushushanya, iri mumatsinda ya code ya modulation. Izindi ni disiki nkuru yibanze ya disiki kimwe na disiki ya disiki ya disiki ikoreshwa muri microcomputer zimwe kugeza mu mpera za 1980. GCR nuburyo bwahinduwe bwa kode ya NRZI, ariko byanze bikunze hamwe ninzibacyuho yo hejuru.
5% 27 / Icyerekezo (biologiya ya molekuline): Icyerekezo , muri biologiya ya biologiya na biohimiya, nicyerekezo cya chimique iherezo-iherezo ryumurongo umwe wa aside nucleique. Mu murongo umwe wa ADN cyangwa RNA, amasezerano y'imiti yo kwita atome ya karubone muri nucleotide pentose-isukari-impeta bivuze ko hazabaho 5 ′ -end, ikunze kuba irimo itsinda rya fosifate ifatanye na 5 ′ karubone ya ribose impeta, hamwe na 3 ′ -end, mubisanzwe idahinduwe kuva ribose -OH. Muri ADN ya kabiri ya helix, imirongo ikora mu cyerekezo gitandukanye kugirango yemererwe guhuza hagati yabo, ni ngombwa mu kwigana cyangwa kwandukura amakuru yashizweho.
5% 27% 27-fosiforiibostamycine fosifata / 5 '' - fosifori ya fosifori: 5 '' - fosiforiibostamycin fosifata (EC 3.1.3.88 , btrP (gene) , neoI (gene) ) ni enzyme ifite izina ritunganijwe 5 -phosiforibostamycin phosphohydrolase . Iyi misemburo itera imiti ikurikira 5 -phosiforibostamycin + H 2 O. ribostamycin + fosifate
5% 27% 27-fosiforiibostamycin fosifogidrolase / 5 '' - fosifori yo mu bwoko bwa fosifori: 5 '' - fosiforiibostamycin fosifata (EC 3.1.3.88 , btrP (gene) , neoI (gene) ) ni enzyme ifite izina ritunganijwe 5 -phosiforibostamycin phosphohydrolase . Iyi misemburo itera imiti ikurikira 5 -phosiforibostamycin + H 2 O. ribostamycin + fosifate
5% 27,5-dibromo-o-cresolsulfonephthalein / Bromocresol yijimye: Bromocresol yijimye ( BCP ) cyangwa 5 ′, 5 ″ -dibromo- o -cresolsulfophthalein , ni irangi ryumuryango wa triphenylmethane hamwe nicyerekana pH. Ifite ibara ry'umuhondo munsi ya pH 5.2, na violet iri hejuru ya pH 6.8. Muburyo bwa cyclic sulfonate ester, ifite p K ifite agaciro ka 6.3, kandi mubisanzwe itegurwa nkigisubizo cyamazi 0,04%.
5% 27,6% 27-Acide Epoxyeicosatrienoic / Acide Epoxyeicosatrienoic: Epoxyeicosatrienoic acide cyangwa EETs yerekana molekile zakozwe mubwoko butandukanye bwingirabuzimafatizo na metabolism ya acide arachidonic hamwe na sisitemu yihariye ya Cytochrome P450 yitwa cytochrome P450 epoxygenase. Iyi eicosanoide idafite classique muri rusange ni iyigihe gito, ihindurwa byihuse kuva muri epoxide ikagera kuri acide idakora cyane cyangwa idakora dihydroxy-eicosatrienoic acide (diHETrEs) na enzyme ikwirakwizwa cyane, Soluble epoxide hydrolase (sEH), nayo yitwa Epoxide hydrolase 2. EETs ikora. nkibikorwa byigihe gito, imisemburo ngufi; ni ukuvuga, bakorera mugace kugirango bagenzure imikorere ya selile zibibyara cyangwa za selile zegeranye. EETs yakozweho ubushakashatsi cyane mubyitegererezo by'inyamaswa aho zigaragaza ubushobozi bwo kugabanya umuvuduko w'amaraso bishoboka ko a) itera vasorelaxation ya arterial na b) kubuza impyiko kugumana imyunyu n'amazi kugirango igabanye umuvuduko w'amaraso. Muri ubu buryo, EET irinda indwara ziterwa na arterial nkumutima ndetse nubwonko bwubwonko ntibiterwa gusa nigikorwa cyo kurwanya hypertension gusa ahubwo birashoboka ningaruka zabyo zo kurwanya indwara zifata imiyoboro y'amaraso, kubuza gukora platine bityo no gutembera kw'amaraso, na / cyangwa kuzamura kwabo gukuraho pro-fibrinolytike yo gukuraho amaraso. Kubijyanye n'ingaruka zabyo kumutima, EET bakunze kwita umutima-urinda. Kurenga kuri ibyo bikorwa byumutima nimiyoboro y'amaraso bishobora gukumira indwara zitandukanye z'umutima-damura, ubushakashatsi bwagize uruhare muri EET mu mikurire y'indwara ya kanseri zimwe na zimwe ndetse no mu myumvire ya physiologique kandi ishobora kuba ari iy'ububabare bwa neuropathique. Mugihe ubushakashatsi kugeza ubu bwerekana ko EETs, EET ikora epoxygenase, hamwe na EET idakora sEH irashobora gukoreshwa muguhashya indwara zitandukanye zabantu, ubushakashatsi bwamavuriro ntiburabigaragaza. Kumenya uruhare rwa EETS mu ndwara zabantu biragoye cyane kubera ubwinshi bwa epoxygenase ya EET ikora, umubare munini wa epoxygenase uterwa na aside arachidonic, hamwe nibikorwa byinshi, bimwe muribi bishobora kuba ari indwara cyangwa bikomeretsa , ko EET ifite.
5% 27-3% 27 / Icyerekezo (biologiya ya molekuline): Icyerekezo , muri biologiya ya biologiya na biohimiya, nicyerekezo cya chimique iherezo-iherezo ryumurongo umwe wa aside nucleique. Mu murongo umwe wa ADN cyangwa RNA, amasezerano y'imiti yo kwita atome ya karubone muri nucleotide pentose-isukari-impeta bivuze ko hazabaho 5 ′ -end, ikunze kuba irimo itsinda rya fosifate ifatanye na 5 ′ karubone ya ribose impeta, hamwe na 3 ′ -end, mubisanzwe idahinduwe kuva ribose -OH. Muri ADN ya kabiri ya helix, imirongo ikora mu cyerekezo gitandukanye kugirango yemererwe guhuza hagati yabo, ni ngombwa mu kwigana cyangwa kwandukura amakuru yashizweho.
5% 27-3% 27 exoribonuclease_1 / XRN1 (gene): 5'-3 'exoribonuclease 1 ( Xrn1 ) ni poroteyine mu bantu igizwe na gen XRN1. Xrn1 hydrolyses RNA muburyo bwa 5 'kugeza 3'.
5% 27-3% 27 exoribonuclease_2 / 5'-3 'exoribonuclease 2: 5'-3 'Exoribonuclease 2 (XRN2) izwi kandi nka Dhm1 isa na poroteyine ni enzyme ya exoribonuclease mu bantu ikozwe na gen XRN2 .
5% 27-AMP / Adenosine monofosifate: Adenosine monophosphate ( AMP ), izwi kandi nka 5'-adenylic aside , ni nucleotide. AMP igizwe nitsinda rya fosifate, isukari ribose, na nucleobase adenine; ni ester ya acide fosifori na nucleoside adenosine. Nkibisimburwa bifata imiterere yinyongera adenylyl- .
5% 27-AMP nucleotidase / 5'-nucleotidase: 5'-nucleotidase ni enzyme itera fosifora ya clavage ya 5'nucleotide. Nubwo mbere yabonetse muburozi bwinzoka, ibikorwa bya 5'nucleotidase byasobanuwe kuri bagiteri na selile, kandi bikwirakwizwa cyane mubice byintangangabo. Mu ngirangingo z'inyamabere enzyme yiganjemo cyane muri plasma membrane kandi uruhare rwibanze rwayo ni uguhindura nucleotide zidasanzwe zidasanzwe, zisanzwe zidashobora kwinjizwa, kuri nucleoside ihuye ishobora kwinjira byoroshye muri selile nyinshi. Kubera iyo mpamvu, enzyme igira uruhare runini muri metabolism ya nucleotide.
5% 27-AMPase / 5'-nucleotidase: 5'-nucleotidase ni enzyme itera fosifora ya clavage ya 5'nucleotide. Nubwo mbere yabonetse muburozi bwinzoka, ibikorwa bya 5'nucleotidase byasobanuwe kuri bagiteri na selile, kandi bikwirakwizwa cyane mubice byintangangabo. Mu ngirangingo z'inyamabere enzyme yiganjemo cyane muri plasma membrane kandi uruhare rwibanze rwayo ni uguhindura nucleotide zidasanzwe zidasanzwe, zisanzwe zidashobora kwinjizwa, kuri nucleoside ihuye ishobora kwinjira byoroshye muri selile nyinshi. Kubera iyo mpamvu, enzyme igira uruhare runini muri metabolism ya nucleotide.
5% 27-Acide Adenylic / Adenosine monofosifate: Adenosine monophosphate ( AMP ), izwi kandi nka 5'-adenylic aside , ni nucleotide. AMP igizwe nitsinda rya fosifate, isukari ribose, na nucleobase adenine; ni ester ya acide fosifori na nucleoside adenosine. Nkibisimburwa bifata imiterere yinyongera adenylyl- .
5% 27-Acide Cytidylic / Cytidine monophosphate: Cytidine monophosphate , izwi kandi nka 5'-cytidylic aside cyangwa cytidylate gusa, hamwe na CMP mu magambo ahinnye, ni nucleotide ikoreshwa nka monomer muri RNA. Ni ester ya acide fosifori hamwe na cytosine nucleoside. CMP igizwe nitsinda rya fosifate, isukari ya pentose ya ribose, na cytosine nucleobase; kubwibyo, ribonucleoside monophosphate.Nkibisimbuza ifata imiterere ya prefix cytidylyl- .
5% 27-DFUR / Doxifluridine: Doxifluridine ni igisekuru cya kabiri nucleoside analog prodrug yakozwe na Roche kandi ikoreshwa nka cytostatike muri chimiotherapie mubihugu byinshi byo muri Aziya harimo Ubushinwa na Koreya yepfo. Doxifluridine ntabwo yemewe na FDA kugirango ikoreshwe muri Amerika. Muri iki gihe kirimo gusuzumwa mu bigeragezo byinshi byo kwa muganga nk'ubuvuzi bwihariye cyangwa buvura.
5% 27-Deoxy-5% 27-fluoroadenosine / 5'-Deoxy-5'-fluoroadenosine: 5'-Deoxy-5'-fluoroadenosine nintambwe yambere muri biosynthesis ya fluoride organic. Ihindurwamo na fluorinase yatangije kongeramo ion ya fluor kuri S -adenosyl- L -methionine , irekura L -methionine nkibicuruzwa. Posine nucleoside fosifora ihuza umuyoboro wa fosifori ya base ya adenine kugirango ubyare 5-fluoro-5-deoxy- D -ribose-1-fosifate .
5% 27-Guanidinonaltrindole / 5'-Guanidinonaltrindole: 5'-Guanidinonaltrindole ( 5'-GNTI ) ni opioid antagonist ikoreshwa mubushakashatsi bwa siyansi ihitamo cyane kuri κ opioid reseptor. Ifite imbaraga 5x kandi inshuro 500 guhitamo kurusha ibisanzwe bikoreshwa κ-opioid antagonist norbinaltorphimine. Ifite buhoro buhoro nigihe kirekire cyibikorwa, kandi itanga ingaruka zirwanya antidepressant mubushakashatsi bwinyamaswa. Yongera kandi allodynia yivanga mubikorwa bya κ-opioid peptide dynorphin.
5% 27-Acide ya Guanidylic / Guanosine monophosphate: Guanosine monophosphate ( GMP ), izwi kandi nka 5'-guanidylic aside cyangwa aside guanylic , ni nucleotide ikoreshwa nka monomer muri RNA. Ni ester ya acide fosifori hamwe na nucleoside guanosine. GMP igizwe nitsinda rya fosifate, isukari ya pentose ya ribose, na nucleobase guanine; niyo mpamvu ari ribonucleoside monophosphate. Guanosine monophosphate ikorwa mubucuruzi na fermentation ya mikorobe. Birazwi nka E nimero E626 .
5% 27-Acide ya Guanylic / Monofosifate ya Guanosine: Guanosine monophosphate ( GMP ), izwi kandi nka 5'-guanidylic aside cyangwa aside guanylic , ni nucleotide ikoreshwa nka monomer muri RNA. Ni ester ya acide fosifori hamwe na nucleoside guanosine. GMP igizwe nitsinda rya fosifate, isukari ya pentose ya ribose, na nucleobase guanine; niyo mpamvu ari ribonucleoside monophosphate. Guanosine monophosphate ikorwa mubucuruzi na fermentation ya mikorobe. Birazwi nka E nimero E626 .
5% 27-Guanylyl imidodiphosphate / 5'-Guanylyl imidodiphosphate: 5'-Guanylyl imidodiphosphate ( GDPNP ) ni nucleotide ya purine. Nibigereranyo bya guanosine triphosphate aho imwe muri atome ya ogisijeni isimburwa na amine, ikabyara itsinda ridafite ingufu za hydrolyzable. Guanylyl imidodiphosphate ihuza cyane na G-proteyine imbere ya Mg 2+ . Guanylyl imidodiphosphate nikintu gikomeye gitera adenylate cyclase. Bikunze gukoreshwa mubushakashatsi bwa synthesis.
5% 27-Methoxyhydnocarpin / 5'-Methoxyhydnocarpin: 5'-Methoxyhydnocarpin ( 5′-MHC ) ni imiti ivangwa na Berberis na Hydnocarpus wightianus .
5% 27-Methyluridine / 5-Methyluridine: Imiti ya 5-methyluridine , nayo yitwa ribothymidine , ni nucleoside ya pyrimidine. Amagambo ahinnye ya m5U, ni mugenzi wa ribonucleoside na thimidine ya deoxyribonucleoside, idafite itsinda rya hydroxyl kumwanya wa 2 '. 5-Methyluridine irimo thymine base ihujwe nisukari ya ribose pentose. Ni umweru ukomeye.
5% 27-NPDase / PDE1: PDE1 ni enzyme ya fosifisiyose izwi kandi nka calcium- na calmoduline-iterwa na fosifori. Nimwe mumiryango 11 ya phosphodiesterase (PDE1-PDE11). PDE1 ifite ubwoko butatu, PDE1A, PDE1B na PDE1C bigabanya cyane muri isoforms zitandukanye. Isoforms zitandukanye zerekana isano itandukanye ya cAMP na cGMP.
5% 27-PDE / PDE1: PDE1 ni enzyme ya fosifisiyose izwi kandi nka calcium- na calmoduline-iterwa na fosifori. Nimwe mumiryango 11 ya phosphodiesterase (PDE1-PDE11). PDE1 ifite ubwoko butatu, PDE1A, PDE1B na PDE1C bigabanya cyane muri isoforms zitandukanye. Isoforms zitandukanye zerekana isano itandukanye ya cAMP na cGMP.
5% 27-PDase / PDE1: PDE1 ni enzyme ya fosifisiyose izwi kandi nka calcium- na calmoduline-iterwa na fosifori. Nimwe mumiryango 11 ya phosphodiesterase (PDE1-PDE11). PDE1 ifite ubwoko butatu, PDE1A, PDE1B na PDE1C bigabanya cyane muri isoforms zitandukanye. Isoforms zitandukanye zerekana isano itandukanye ya cAMP na cGMP.
% 5 5'-Phosphoribosyl-4-carboxy-5-aminoimidazole ni intera yo gukora purine.
5% 27-Fosiforiibosil-5-aminoimidazole / 5-Aminoimidazole ribotide: 5'-Phosphoribosyl-5-aminoimidazole ni intera mugukora purine. Rero, ni intera hagati yinzira ya adenine, kandi ikomatanyirizwa muri 5'-fosiforiibosylformylglycinamidine na synthetase ya AIR.
5% 27-Fosiforiibosylformylglycinamidine / 5'-Fosiforibosylformylglycinamidine: 5'-Phosphoribosylformylglycinamidine ni intera hagati muri synthesis ya purine.
5% 27-ISOKO / Kwiyongera byihuse kwa cDNA birangira: Kwiyongera kwihuse kwa cDNA birangira ( RACE ) nubuhanga bukoreshwa muri biyolojiya ya molekuline kugirango ubone uburebure bwuzuye bwinyandiko ya RNA iboneka mu kagari. ISOKO ritanga umusaruro wa cDNA ya kopi ya RNA ikurikirana yinyungu, yakozwe binyuze mumyandikire yinyuma, ikurikirwa na PCR yongerewe kopi ya cDNA. Amakopi ya cDNA yongerewe hanyuma akurikiranwa kandi, niba ari maremare bihagije, agomba gushushanya mukarere kihariye. ISOKO risanzwe rikurikiranwa no gukoroniza mbere yo gukurikiranya ibyari bisanzwe molekile ya RNA. Birenzeho-byinjira mubindi bisobanuro bifite akamaro mukumenyekanisha inyandiko-mvugo yubushakashatsi, ni ugukurikirana RACE-ibicuruzwa byikoranabuhanga bizakurikiraho.
5% 27-Acide ya Thymidylic / Thymidine monophosphate: Thymidine monophosphate ( TMP ), izwi kandi nka acide thymidylic , deoxythymidine monophosphate ( dTMP ), cyangwa aside deoxythymidylic , ni nucleotide ikoreshwa nka monomer muri ADN. Ni ester ya aside ya fosifori hamwe na nucleoside thymidine. dTMP igizwe nitsinda rya fosifate, isukari ya pentose deoxyribose, na nucleobase thymine. Bitandukanye nizindi deoxyribonucleotide, thimidine monophosphate akenshi ntabwo irimo prefix "deoxy" mwizina ryayo; nyamara, ikimenyetso cyacyo gikubiyemo "d" ("dTMP"). Inkoranyamagambo ya Dorland Illustrated Medical Dictionary itanga ibisobanuro byerekana itandukaniro rya nomenclature aho ryinjiye kuri thymidine.
5% 27-Acide ya Uridylic / Uridine monophosphate: Uridine monophosphate ( UMP ), izwi kandi nka 5′-uridylic aside , ni nucleotide ikoreshwa nka monomer muri RNA. Ni ester ya aside ya fosifori hamwe na nucleoside uridine. UMP igizwe nitsinda rya fosifate, isukari ya pentose ya ribose, na nucleobase uracil; kubwibyo, ni monofosifate ya ribonucleotide. Nkibisimbuza cyangwa bikabije izina ryayo rifata imiterere ya prefix uridylyl- . Ifishi ya deoxy ni impfunyapfunyo ya DUMP. Covalent attachment ya UMP yitwa uridylylation .
5% 27-acylphosphoadenosine acylhydrolase / 5'-acylphosphoadenosine hydrolase: Muri enzymologiya, hydrolase ya 5'-acylphosphoadenosine (EC 3.6.1.20 ) ni enzyme itera reaction yimiti 5'-acylphosphoadenosine + H 2 O. AMP + karubasi
5% 27-acylphosphoadenosine hydrolase / 5'-acylphosphoadenosine hydrolase: Muri enzymologiya, hydrolase ya 5'-acylphosphoadenosine (EC 3.6.1.20 ) ni enzyme itera reaction yimiti 5'-acylphosphoadenosine + H 2 O. AMP + karubasi
5% 27-acide adenylic / Adenosine monofosifate: Adenosine monophosphate ( AMP ), izwi kandi nka 5'-adenylic aside , ni nucleotide. AMP igizwe nitsinda rya fosifate, isukari ribose, na nucleobase adenine; ni ester ya acide fosifori na nucleoside adenosine. Nkibisimburwa bifata imiterere yinyongera adenylyl- .
5% 27-fosifata ya adenylic / 5'-nucleotidase: 5'-nucleotidase ni enzyme itera fosifora ya clavage ya 5'nucleotide. Nubwo mbere yabonetse muburozi bwinzoka, ibikorwa bya 5'nucleotidase byasobanuwe kuri bagiteri na selile, kandi bikwirakwizwa cyane mubice byintangangabo. Mu ngirangingo z'inyamabere enzyme yiganjemo cyane muri plasma membrane kandi uruhare rwibanze rwayo ni uguhindura nucleotide zidasanzwe zidasanzwe, zisanzwe zidashobora kwinjizwa, kuri nucleoside ihuye ishobora kwinjira byoroshye muri selile nyinshi. Kubera iyo mpamvu, enzyme igira uruhare runini muri metabolism ya nucleotide.
5% 27-bromotetrafucol-A / Tetrafucol A: Tetrafucol A ni florotannine yo mu bwoko bwa fucol iboneka muri algae yijimye Ascophyllum nodosum , Analipus japonicus na Scytothamnus australis .
5% 27-chloro-5% 27-synthase ya deoxyadenosine / synthase ya Adenozil-chloride: Adenosyl-chloride synthase ni enzyme ifite izina ritunganijwe S-adenosyl-L-methionine: chloride adenosyltransferase . Iyi misemburo itera imiti ikurikira S-adenosyl-L-methionine + chloride 5-deoxy-5-chloroadenosine + L-methionine
5% 27-chlorotetrafucol-A / Tetrafucol A: Tetrafucol A ni florotannine yo mu bwoko bwa fucol iboneka muri algae yijimye Ascophyllum nodosum , Analipus japonicus na Scytothamnus australis .
5% 27-acide ya cytidilike / Cytidine monophosphate: Cytidine monophosphate , izwi kandi nka 5'-cytidylic aside cyangwa cytidylate gusa, hamwe na CMP mu magambo ahinnye, ni nucleotide ikoreshwa nka monomer muri RNA. Ni ester ya acide fosifori hamwe na cytosine nucleoside. CMP igizwe nitsinda rya fosifate, isukari ya pentose ya ribose, na cytosine nucleobase; kubwibyo, ribonucleoside monophosphate.Nkibisimbuza ifata imiterere ya prefix cytidylyl- .
5% 27-dFUrd / Doxifluridine: Doxifluridine ni igisekuru cya kabiri nucleoside analog prodrug yakozwe na Roche kandi ikoreshwa nka cytostatike muri chimiotherapie mubihugu byinshi byo muri Aziya harimo Ubushinwa na Koreya yepfo. Doxifluridine ntabwo yemewe na FDA kugirango ikoreshwe muri Amerika. Muri iki gihe kirimo gusuzumwa mu bigeragezo byinshi byo kwa muganga nk'ubuvuzi bwihariye cyangwa buvura.
5% 27-deoxy-5% 27-fluoroadenosine / 5'-Deoxy-5'-fluoroadenosine: 5'-Deoxy-5'-fluoroadenosine nintambwe yambere muri biosynthesis ya fluoride organic. Ihindurwamo na fluorinase yatangije kongeramo ion ya fluor kuri S -adenosyl- L -methionine , irekura L -methionine nkibicuruzwa. Posine nucleoside fosifora ihuza umuyoboro wa fosifori ya base ya adenine kugirango ubyare 5-fluoro-5-deoxy- D -ribose-1-fosifate .
5% 27-deoxyadenosine deaminase / 5'-deoxyadenosine deaminase: 5'-deoxyadenosine deaminase ni enzyme itera ihinduka rya 5′-deoxyadenosine kuri 5′-deoxyinosine. Ku rugero ruto, enzyme nayo itera kwanduza 5′-methylthioadenosine, S -adenosylhomocysteine, na adenosine. Imisemburo ya molekile ya enzyme ya DadD igera kuri 230 kDa. DadD ikomeza 90% yibikorwa byayo byimisemburo nyuma yo gushyuha kuri dogere selisiyusi 60 muminota icumi. PH ikunzwe kuri 5'deoxyadenosine deaminase ni 9.0, hamwe na enzyme yerekana kuri pH ya 11. Enzyme ya DadD ifite substrate ikunzwe ya 5'deoxyadenosine, nubwo izakora na 5′-methylthioadenosine, S -adenosylhomocysteine, na adenosine ku bushobozi buke.
5% 27-iherezo / Icyerekezo (biologiya ya molekuline): Icyerekezo , muri biologiya ya biologiya na biohimiya, nicyerekezo cya chimique iherezo-iherezo ryumurongo umwe wa aside nucleique. Mu murongo umwe wa ADN cyangwa RNA, amasezerano y'imiti yo kwita atome ya karubone muri nucleotide pentose-isukari-impeta bivuze ko hazabaho 5 ′ -end, ikunze kuba irimo itsinda rya fosifate ifatanye na 5 ′ karubone ya ribose impeta, hamwe na 3 ′ -end, mubisanzwe idahinduwe kuva ribose -OH. Muri ADN ya kabiri ya helix, imirongo ikora mu cyerekezo gitandukanye kugirango yemererwe guhuza hagati yabo, ni ngombwa mu kwigana cyangwa kwandukura amakuru yashizweho.
5% 27-exonuclease / PDE1: PDE1 ni enzyme ya fosifisiyose izwi kandi nka calcium- na calmoduline-iterwa na fosifori. Nimwe mumiryango 11 ya phosphodiesterase (PDE1-PDE11). PDE1 ifite ubwoko butatu, PDE1A, PDE1B na PDE1C bigabanya cyane muri isoforms zitandukanye. Isoforms zitandukanye zerekana isano itandukanye ya cAMP na cGMP.
5% 27-exoribonuclease / Exoribonuclease II: Exoribonuclease II ni enzyme. Iyi misemburo itera imiti ikurikira Exonucleolytic clavage muri 3'- kugeza 5'-icyerekezo cyo gutanga nucleoside 5'-fosifate